摘要
目的 探讨骨肉瘤组织中CD44、CD44V3、CD44V6及PCNA的表达情况及其临床意义。方法 应用免疫组织化学方法对 40例骨肉瘤、15例骨软骨瘤中CD44、CD44V3、CD44V6及PCNA的表达情况进行检测 ,并结合临床资料分析其与肿瘤恶性程度和预后的关系。结果 ①骨肉瘤中CD44、CD44V3、CD44V6阳性表达率明显高于骨软骨瘤。②骨肉瘤中CD44V6阳性表达率明显高于CD44、CD44V3。③骨肉瘤组织中CD44V6的表达与临床病理类型无关 ,与预后无关。④CD44及CD44V6的表达与PCNA的关系密切 ,尤以CD44V6更能反映肿瘤的恶性程度。结论 CD44V6可作为骨肿瘤恶性表型的标志 。
Objective To explore the expressions of CD44, CD44V3, CD44V6 and PCNA and the relationship between the expressions and clinical pathologic changes of human osteosarcoma Methods The expressions of CD44, CD44V3, CD44V6 and PCNA in 15 osteochondromas and 40 osteosarcomas were detected immunohistochemically Results (1) The positive expression rates of CD44, CD44V3 and CD44V6 in osteosarcoma were markedly higher than those in osteochondroma (2) The positive expression rate of CD44V6 was higher than those of CD44 and CD44V3 in osteochondroma (3) The expression of CD44V6 was not involved in the pathological type or the prognosis in osteochondroma (4) The expressions of CD44 and CD44V6, particularly that of CD44V6, were closely involved in the PCNA positive rate Conclusion CD44V6 might act as a marker of malignancy of the bone tumors, but the relationship with the prognosis in malignant bone tumors waits to be further studied
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2003年第10期874-876,共3页
Journal of Third Military Medical University
