摘要
目的 探讨骨肉瘤组织中MMP-9、CD44v6的表达及其临床意义。方法 应用免疫组化方法检测70例骨肉瘤、15例骨软骨瘤和15例正常骨组织中CD44v6和MMP-9的表达情况,分析其相关的临床病理因素,并进行回顾性随访。结果 在骨肉瘤组织中,MMP-9、CD44v6阳性表达率明显高于骨软骨瘤和正常骨组织;MMP-9阳性表达与骨肉瘤软组织侵袭及预后有一定关系;CD44v6的表达与MMP-9的表达呈正相关的关系。结论 CD44v6与MMP-9均可作为骨肿瘤恶性表型的辅助指标;MMP-9与骨肉瘤的侵袭、转移相关,可作为预测骨肉瘤转移潜能的指标。
Objective To detect the expression of CD44v6 and MMP- 9 in osteosarcoma and discuss their clinical significance. Method The expression of MMP-9 and CD44V6 were evaluated by immunohistochemical methods in 70 specimens of osteosarcoma, 15 exostosis and 15 normal bone tissue. Results The expression of MMP- 9 and CD44v6 in osteosarcoma is much higher than that in esostosis and normal bone tissue. The expression of MMP - 9 is significantly and positively related to the soft tissue invasion. There is certain correlation between the expression of MMP-9 and the prognosis of patients with osteosarcoma. The contributions of positive expression of CD44v6 and MMP-9 to invasion in osteosarcoma may possibly be a coordination effects between the two markers. Conclusion Both MMP - 9 and CD44v6 may act as adjuvant indicators in the grade of malignancy of os-teosarcomas. MMP - 9 has a correlation with the invasion and metastasis of osteosarcoma, and may act as an indicator for predicting the possibility of metastasis of osteosarcoma.
出处
《中国骨肿瘤骨病》
CAS
2002年第1期35-37,共3页
Chinse Journal Of Bone Tumor And Bone Disease
