摘要
综述了近年来大环内酯类抗肿瘤药埃坡霉素的研究进展。简要介绍了其作用机制、药理活性和临床疗效 ,重点对埃坡霉素的构效关系以及若干种全合成策略 ,如大环内酯化合成、烯烃转化 /Stille偶合等方法进行了分析和介绍。
The development of acting mechanism, biological activity, clinical efficacy and Structure activity relationships of the Epothilones, a new class of antitumour agent were reported. The total synthesis of Epothilones and its analogs,such as macrolactonzation strategy and olefin metathesis/stille couling strategy, were reviewed.
出处
《药学进展》
CAS
2004年第8期354-361,共8页
Progress in Pharmaceutical Sciences
关键词
埃坡霉素
抗肿瘤活性
作用机制
临床疗效
构效关系
全合成
Epothilones,Antitumour activity,Action mechanism,Clinical efficacy,Structure-activity relationships,Total synthesis
