摘要
目的制备抗肿瘤药物多西他赛脂质体,为下一步进行动物实验和临床研究奠定基础。方法采用乳化挥散法制备多西他赛脂质体,优化处方中大豆磷脂-鱼油乙酯-胆固醇硫酸钠-多西他赛(SPC-EPA-SCS-DOC)物质的量比为7∶1.8∶1.2∶1,并对其理化性质进行了考察。结果制备的多西他赛脂质体形态理想,粒径分布均匀,平均直径约(110±10)nm,包封率为95%以上,符合静脉给药的要求。结论该方法制备多西他赛脂质体简便易行,方法可靠。
Objective To optimize the formulation of liposomes containing docetaxel in order to select the best one for animal experiments and clinical applications. Method Liposomes containing docetaxel were prepared using emulsifying-volatilizing technology, and composition of SPC-EPA-SCS-DOC (n : n : n : n = 7:1.8:1.2:1) was demonstrated to be the most effective. The physico-chemical properties of the liposomes were characterized. Result The prepared liposomes were small in size and welldistributed. The average size and entrapment efficiency were(110 ± 10)nm and above 95% ,respectively. It can be used for intravenous injection. Conclusion A simple, reliable method was established for liposomes containing docetaxel preparation.
出处
《中国药剂学杂志（网络版）》
2009年第1期1-5,共5页
Chinese Journal of Pharmaceutics：Online Edition
关键词
药剂学
脂质体
乳化挥散
多西他赛
理化性质
pharmaceutics
liposome
emulsifying-volatilizing
docetaxel
physico-chemical property
