摘要
Objective: To study the effect of multimodal analgesia + preemptive analgesia on the postoperative recovery of elderly patients with hip replacement, and observe its effect on the postoperative pain-related neurotransmitters, inflammatory factors and stress response. Methods: Elderly patients who received hip replacement in the hospital between February 2015 and December 2016 were selected and randomly divided into preemptive analgesia group, multimodal analgesia group and combined analgesia group. Serum levels of pain-related neurotransmitters, inflammatory factors and stress response molecules were detected before surgery as well as 6 h and 24 h after surgery. Results: Serum SP, PGE2, NO, 5-HT, ICAM-1, hs-CRP, IL-6, IL-10, Cor, NE and MDA levels of three groups of patients 6 h and 24 h after surgery were significantly higher than those before surgery, and serum SP, PGE2, NO, 5-HT, ICAM-1, hs-CRP, IL-6, IL-10, Cor, NE and MDA levels of combined analgesia group 6 h and 24 h after surgery were significantly lower than those of preemptive analgesia group and multimodal analgesia group. Conclusion: Multimodal analgesia + preemptive analgesia can be more effective than multimodal analgesia and preemptive analgesia in reducing postoperative pain, inflammatory response and stress response in elderly patients with hip replacement.
作者简介
Corresponding author:Ting-Ting Wen,Department of Anesthesiology,Mianyang Central Hospital in Sichuan Province,Mianyang City,Sichuan Province,621000,P.R.China.
