摘要
Objective:To study the clinical value of dexmedetomidine for adjuvant anesthesia and analgesia in elderly patients undergoing hip replacement.Methods: The elderly patients undergoing hip replacement in our hospital between March 2015 and February 2018 were randomly divided into the control group receiving general anesthesia and the observation group receiving dexmedetomidine combined with general anesthesia. The operative conditions were observed and the serum contents of pain mediators, inflammatory factors and oxidative stress indexes were measured.Results: There was no significant difference in operation time, bleeding volume, intraoperative mean diastolic blood pressure and intraoperative heart rate between the two groups. During operation, serum contents of neuropeptide Y (NPY), substance P (SP), prostaglandin E2 (PGE2), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-18 (IL-18), malondialdehyde (MDA), adrenocorticotropic hormone (ACTH), cortisol (Cor) and norepinephrine (NE) of the observation group were significantly lower than those of the control group while serum content of superoxide dismutase (SOD) was significantly higher than that of the control group (P<0.05).Conclusion: The adjuvant anesthesia and analgesia with dexmedetomidine in elderly patients undergoing hip replacement will not affect the operation and can alleviate the pain, inflammation and oxidative stress during the operation.
作者简介
Corresponding author:Yu Yang,Department of Anesthesiology,Mianyang Central Hospital,Mianyang,Sichuan Province,621000,China.
