摘要
Objective:To study the effect of sufentanil analgesia for hip replacement on pain mediator, stress hormone and inflammatory cytokine secretion.Methods: Patients who underwent hip replacement in People's Hospital of Dongxihu District Wuhan between August 2015 and October 2017 were selected as the research subjects and randomly divided into the sufentanil group who accepted postoperative sufentanil analgesia and the fentanyl group who accepted postoperative fentanyl analgesia. The expression levels of pain mediators and inflammatory cytokines in peripheral blood as well as the levels of pain mediators, stress hormones and inflammatory cytokines in serum were measured 1 day and 3 days after surgery.Results:Serum PGE2, SP,β-EP, GH, COR, ACTH, INS, AT-II, TNF-α and ICAM-1 levels as well as peripheral blood MKP1, p38MAPK, Caspase-1, IL-1β and IL-18 expression intensity of sufentanil group 1 day and 3 days after surgery were significantly lower than those of fentanyl group.Conclusion: Sufentanil analgesia for hip replacement can be more effective than fentanyl to reduce the secretion of pain mediators, stress hormones and inflammatory cytokines.
作者简介
Corresponding author:Ling Wei,Anesthesiology Department,People’s Hospital of Dongxihu District in Wuhan in Hubei Province,Wuhan,Hubei Province,430040,China.
