摘要
目的:探讨血浆EBV DNA和VCA-IgA联合检测在监测鼻咽癌患者放疗后复发和转移中的临床价值。方法分别采用荧光定量PCR法和常规免疫酶法检测放疗前后各组鼻咽癌患者血浆EBV DNA含量与血浆VCA-IgA滴度,并进行比较分析。结果放疗前组(初诊)患者血浆EBV DNA和VCA-IgA阳性率显著高于放疗后缓解组(<0.01),与复发或转移组比较无显著性差异(>0.05);复发或转移组与放疗后缓解组比较有显著性差异(<0.01)。结论血浆EBV DNA和VCA-IgA的联合检测是监测鼻咽癌患者放疗后复发和转移的有效标记物。
Objective To evaluate the clinical significance of quantitative analysis of EBV DNA and VCA-IgA in plasma of nasopharyngeal carcinoma patients after curative radiotherapy.Methods Using the method of PCR to test plasma EBV DNA and the method of immunoenzyme to test VCA-IgA.Results The positive rates of XRT Preoperative radiotherapy groups was significantly higher than clinical remission groups(<0.01),and there is no statistical significance between clinical remission and recurrent groups(>0.05).However,There were significant difference in recurrent or metastasis groups and clinical remission(<0.01).Conclusion The detection of Plasma EBV DNA and VCA-IgA is useful for surveillance of nasopharynged carcinoma patients following radiotherapy.The simultaneous combination tests can rise advantage to each other.
作者
孙琦
邓展锋
史顺畅
孙剑光
SUN Qi;DENG Zhan-feng;SHI Shun-chang;SUN Jian-guang(Affilicated Hospital of Shaoyang Medical College,Shaoyang 422000,Hunan,China)
基金
邵阳医学高等专科学校科研项目(编号:xk201504)。
作者简介
通讯作者:孙剑光(1963~)男,湖南人,教授,研究方向:鼻咽癌防治的研究。
