摘要
目的探讨蒙脱石散、双歧杆菌四联活菌片、葡萄糖酸锌口服液三种药物联合治疗方案在迁延性慢性腹泻患儿中的应用效果及对其免疫功能的影响.方法选取该院2017年5月—2018年10月收治的58例迁延性慢性腹泻患儿为研究对象,将其随机分为两组,各29例.予以对照组患儿蒙脱石散和双歧杆菌四联活菌片治疗,予以观察组患儿蒙脱石散、双歧杆菌四联活菌片联合葡萄糖酸锌口服液治疗.比较两组患儿的治疗效果、相关临床指标、胃肠道症状及免疫功能.结果两组治疗总有效率比较,观察组93.10%高于对照组的72.41%,差异有统计学意义(P<0.05).观察组住院时间、大便性状恢复正常时间、大便次数恢复正常时间、退热时间分别为(4.13±2.22)d、(3.26±1.29)d、(3.62±1.15)d、(2.12±0.86)d,均短于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组腹泻、腹痛、腹胀评分分别为(0.81±0.04)分、(0.72±0.03)分、(0.82±0.02)分,均比对照组低,组间差异有统计学意义(P<0.05).两组治疗后的T淋巴细胞亚群CD_(4)^(+)、CD_(3)^(+)、免疫球蛋白(immunoglobulin,Ig)A、IgG水平与治疗前相比均升高,CD_(8)^(+)水平与治疗前相比均降低,差异有统计学意义(P<0.05).治疗后,观察组CD_(4)^(+)、CD_(3)^(+)、IgA、IgG水平与对照组相比均更高,CD_(8)^(+)水平与对照组相比更低,组间差异有统计学意义(P<0.05).结论蒙脱石散、双歧杆菌四联活菌片、葡萄糖酸锌口服液三种药物联合治疗方案在迁延性慢性腹泻患儿中的临床应用效果显著,能有效提高患儿的免疫力,值得临床推广应用.
Objective To explore the application effect of the three-drug combination treatment plan of montmorillonite powder,bifidobacterium quadruple viable bacteria tablets and zinc gluconate oral liquid in children with persistent chronic diarrhea and its influence on the immune function.Methods A total of 58 children with persistent chronic diarrhea admitted to the hospital from May 2017 to October 2018 were selected as the research objects,and they were randomly divided into two groups,with 29 cases in each group.The children in the control group were treated with montmorillonite powder and bifidobacterium quadruple viable bacteria tablets,and the observation group was treated with montmorillonite powder and bifidobacterium quadruple viable bacteria tablets combined with zinc gluconate oral liquid.The treatment effect,related clinical indicators,gastrointestinal symptoms and immune function of the two groups of children were compared.Results Comparing the total effective rate of treatment between the two groups,93.10%of the observation group was higher than 72.41%of the control group,and the difference was statistically significant(P<0.05).In the observation group,the hospitalization time,the time for stool characteristics to return to normal,the time for stool frequency to return to normal,and the time to reduce fever were(4.13±2.22)d,(3.26±1.29)d,(3.62±1.15)d,(2.12±0.86)d,respectively,Which were shorter than those of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the scores of diarrhea,abdominal pain,and abdominal distension in the observation group were(0.81±0.04)points,(0.72±0.03)points,and(0.82±0.02)points respectively,which were lower than those of the control group,and the difference between the groups was statistically significant(P<0.05).After treatment,the levels of T lymphocyte subgroups CD_(4)^(+),CD_(3)^(+),immunoglobulin(Ig)A,and IgG in the two groups increased compared with before treatment,and CD_(8)^(+)levels decreased compared with before treatment,and the differences were statistically significant(P<0.05).After treatment,the observation group's CD_(4)^(+),CD_(3)^(+),IgA,and IgG levels were higher than those of the control group,and the CD_(8)^(+)levels were lower than the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Montmorillonite powder,Bifidobacterium quadruple viable bacteria tablets,and zinc gluconate oral liquid have a significant clinical application effect in children with persistent chronic diarrhea,which can effectively improve the immunity of children and is worthy of clinical application.
作者
陈妍春
CHEN Yanchun(Department of Pediatrics,Yantai Oriental Hospital,Yantai Shandong,264000,China)
出处
《反射疗法与康复医学》
2021年第11期57-59,63,共4页
Reflexology And Rehabilitation Medicine
关键词
迁延性慢性腹泻
葡萄糖酸锌口服液
蒙脱石散
双歧杆菌四联活菌片
Persistent chronic diarrhea
Zinc gluconate oral liquid
Montmorillonite powder
Bifidobacterium quadruple viable tablet
作者简介
陈妍春(1984-),女,山东招远人,本科,主治医师,研究方向:儿内科呼吸系统及消化系统常见病及多发病治疗。
