摘要
目的 研究肝爽颗粒联合恩替卡韦治疗早期乙型肝炎肝硬化患者的疗效及对其免疫功能和肝纤维化指标的影响.方法 选取2019年10月—2021年4月我院收治的125例早期乙型肝炎肝硬化患者为研究对象,随机分为观察组(n=63)和对照组(n=62).对照组采用恩替卡韦治疗,观察组采用肝爽颗粒联合恩替卡韦治疗,均持续治疗6个月.观察并比较两组的临床疗效、治疗前后肝功能、免疫功能和肝纤维化指标变化情况.结果 观察组治疗总有效率88.89%明显高于对照组的67.74%,差异有统计学意义(P<0.05).治疗后,观察组谷丙转氨酶、谷草转氨酶、总胆红素水平均明显低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均明显高于对照组,层粘连蛋白、Ⅲ型前胶原、Ⅳ型胶原、透明质酸水平均明显低于对照组,组间差异有统计学意义(P<0.05).治疗期间,对照组不良反应发生率为17.74%,观察组不良反应发生率为20.63%,两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 临床采用肝爽颗粒联合恩替卡韦治疗早期乙型肝炎肝硬化患者的疗效显著,能有效改善患者的肝功能、免疫功能和肝纤维化指标,且安全可靠.
Objective To study the efficacy of Ganshuang granule combined with entecavir in the treatment of patients with early stage hepatitis B cirrhosis and its effect on immune function and liver fibrosis indicators.Methods A total of 125 patients with early stage hepatitis B cirrhosis who were admitted to our hospital from October 2019 to April 2021 were selected as the research objects,and they were randomly divided into an observation group(n=63)and a control group(n=62).The control group was treated with entecavir,and the observation group was treated with Ganshuang granules combined with entecavir.Both groups were treated for 6 months.The clinical efficacy,liver function,immune function and changes of liver fibrosis indexes before and after treatment were observed and compared between the two groups.Results The total effective rate of treatment in the observation group was 88.89%,which was significantly higher than 67.74%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of alanine aminotransferase,aspartate aminotransferase and total bilirubin in the observation group were significantly lower than those in the control group,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were significantly higher than those in the control group,the levels of laminin,procollagen type III,collagen type IV,and hyaluronic acid were significantly lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).During the treatment period,the incidence of adverse reactions in the control group was 17.74%,and the incidence of adverse reactions in the observation group was 20.63%,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Clinical use of Ganshuang granules combined with entecavir in the treatment of patients with early stage hepatitis B cirrhosis has a significant effect,can effectively improve the patients'liver function,immune function and liver fibrosis indicators,and is safe and reliable.
作者
张洋
ZHANG Yang(Department of Infectious Liver Diseases,Zaozhuang Municipal Hospital,Zaozhuang Shandong,277100,China)
出处
《反射疗法与康复医学》
2022年第6期79-82,共4页
Reflexology And Rehabilitation Medicine
关键词
乙型肝炎肝硬化
早期
肝爽颗粒
恩替卡韦
免疫功能
肝纤维化
Hepatitis B liver cirrhosis
Early stage
Ganshuang granules
Entecavir
Immune function
Liver fibrosis
作者简介
张洋(1975-),女,安徽淮南人,硕士研究生,副主任医师,研究方向:传染病治疗。
