摘要
目的观察肝爽颗粒联合恩替卡韦胶囊治疗乙肝肝硬化的临床效果。方法选取2022年2月—2023年2月于淮安市第四人民医院接受治疗的乙肝肝硬化患者74例,以随机数字表法分为联合肝爽颗粒组和恩替卡韦组,各37例。恩替卡韦组予常规药物恩替卡韦胶囊治疗,联合肝爽颗粒组在恩替卡韦组基础上增加肝爽颗粒治疗,2组均以1个月为1个疗程,持续治疗4个疗程。比较2组治疗前后临床症状评分、肝功能、肝纤维化指标及不良反应。结果与治疗前比较,治疗4个疗程后,2组腹胀、肝区疼痛、疲乏评分,总胆红素、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、血清透明质酸、Ⅲ型前胶原、Ⅳ型胶原水平降低,且联合肝爽颗粒组低于恩替卡韦组(P均<0.01)。联合肝爽颗粒组与恩替卡韦组不良反应总发生率比较无统计学差异(5.41%vs.10.81%,χ^(2)=0.181,P=0.670)。结论肝爽颗粒联合恩替卡韦治疗乙肝肝硬化有助于改善患者相关临床症状和肝功能,有效抑制肝纤维化,且不会增加不良反应。
Objective To observe the clinical effect of Ganshuang granules combined with entecavir capsules in the treatment of hepatitis B cirrhosis.Methods Seventy four patients with hepatitis B cirrhosis who were treated in Huai′an No.4 People′s Hospital from February 2022 to February 2023 were selected and randomly divided into the combined Ganshuang granules group and entecavir group,37 cases in each group.The entecavir group was treated with entecavir capsules,and the combined Ganshuang granules group was treated with Ganshuang granules on the basis of entecavir group.Both groups were treated with 1 month as a course of treatment,lasting for 4 courses.The clinical symptom score,liver function,liver fibrosis index before and after treatment,and adverse reactions were compared between the two groups.Results Compared with before treatment,after 4 courses of treatment,abdominal distension,liver pain,fatigue scores,TBil,AST,ALT,serum hyaluronic acid,typeⅢprocollagen,typeⅣcollagen levels in the two groups were decreased,and the combined Ganshuang granules group were lower than those in the entecavir group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the combined Ganshuang granules group and entecavir group(5.41%vs.10.81%,χ^(2)=0.181,P=0.670).Conclusion Ganshuang granules combined with entecavir in the treatment of hepatitis B cirrhosis can help improve the relevant clinical symptoms and liver function of patients,effectively inhibit liver fibrosis,and will not increase adverse reactions.
作者
蒋坤
JIANG Kun(Department of Pharmacy,Huai′an No.4 People′s Hospital,Jiangsu Province,Huai′an 223002,China)
出处
《临床合理用药》
2025年第5期31-34,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
乙肝肝硬化
肝爽颗粒
恩替卡韦
肝功能
肝纤维化
Hepatitis B cirrhosis
Ganshuang granules
Entecavir
Liver function
Liver fibrosis
