摘要
目的探讨急性脑梗死患者采用奥扎格雷联合小牛血清去蛋白治疗的临床效果及对其血小板参数、脑血管储备功能的影响。方法选取淄博市张店区中医院2022年6月—2023年6月收治的88例急性脑梗死患者为研究对象,按随机数表法将其分为对照组及观察组。对照组(n=44)采用奥扎格雷治疗,观察组(n=44)在此基础上采用小牛血清去蛋白治疗。对比两组患者的治疗效果、血小板参数、脑血管储备功能、脑血流动力学及梗死灶体积。结果观察组的治疗总有效率为90.91%,高于对照组的70.45%,差异有统计学意义(P<0.05)。治疗后,观察组的血小板分布宽度、血小板聚集率、血浆黏度、搏动指数分别为(13.34±1.92)%、(26.78±2.28)%、(0.55±0.16)%、(0.72±0.18),均低于对照组的(16.06±1.99)%、(29.35±2.75)%、(1.12±0.08)%、(0.81±0.19),平均血小板体积、梗死灶体积分别为(7.07±1.36)fl、(2.21±0.32)cm^(3),均小于对照组的(9.15±1.32)fl、(2.79±0.41)cm^(3),血小板计数、脑血管储备功能分别为(191.69±24.22)×10^(9)/L、(39.45±2.75)%,均高于对照组的(180.85±25.05)×10^(9)/L、(33.77±2.94)%,大脑平均血液流速为(80.28±4.96)cm/s,快于对照组的(74.27±4.38)cm/s,组间差异有统计学意义(P<0.05)。结论急性脑梗死患者采用奥扎格雷联合小牛血清去蛋白治疗,能改善血小板参数,提升脑血管储备功能,临床疗效确切。
Objective To investigate the clinical effect of ozagrel combined with calf serum deproteinization in patients with acute cerebral infarction and its effect on platelet parameters and cerebral vascular reserve function.Methods 88 patients with acute cerebral infarction admitted to Zhangdian Hospital of Traditional Chinese Medicine of Zibo City from June 2022 to June 2023 were selected and were divided into a control group and an observation group according to random number table method.The control group(n=44)was treated with ozagrel,and the observation group(n=44)was treated with calf serum deproteinization on this basis.The therapeutic effect,platelet parameters,cerebral vascular reserve function,cerebral hemodynamics and infarct volume were compared between the two groups.Results The total effective rate of the observation group was 90.91%,which was higher than 70.45%of the control group,the difference was statistically significant(P<0.05).After treatment,the platelet distribution width,platelet aggregation rate,plasma viscosity and pulsatility index of the observation group were(13.34±1.92)%,(26.78±2.28)%,(0.55±0.16)%and(0.72±0.18),respectively,which were lower than(16.06±1.99)%,(29.35±2.75)%,(1.12±0.08)%,(0.81±0.19)of the control group,the mean platelet volume and infarct volume were(7.07±1.36)fl and(2.21±0.32)cm^(3),respectively,which were lower than(9.15±1.32)fl and(2.79±0.41)cm^(3) of the control group,the platelet count and cerebrovascular reserve function of the observation group were(191.69±24.22)×10^(9)/L and(39.45±2.75)%,respectively,which were higher than(180.85±25.05)×10^(9)/L and(33.77±2.94)%of the control group,the average cerebral blood flow velocity was(80.28±4.96)cm/s,which was faster than(74.27±4.38)cm/s in the control group,and the differences between the two groups were statistically significant(P<0.05).Conclusion Ozagrel combined with calf serum deproteinization can improve platelet parameters and cerebral vascular reserve function in patients with acute cerebral infarction.
作者
窦鹏
DOU Peng(Department of Neurology,Zhangdian Hospital of Traditional Chinese Medicine,Zibo City,Zibo Shandong,255035,China)
出处
《反射疗法与康复医学》
2023年第24期112-115,共4页
Reflexology And Rehabilitation Medicine
关键词
急性脑梗死
小牛血清去蛋白
奥扎格雷
血小板
脑血管储备功能
Acute cerebral infarction
Calf serum deproteinization
Ozagre
Platelets
Cerebral vascular reserve function
作者简介
窦鹏(1978-),男,山东淄博人,本科,副主任医师,研究方向:神经内科疾病诊治。
