摘要
目的探究丁苯酞辅助治疗对急性脑梗死溶栓后患者的影响。方法回顾性分析2022年1月—12月济南市第三人民医院收治的90例急性脑梗死患者的临床资料,按治疗方法不同分为观察组(n=45)及对照组(n=45)。对照组采用阿替普酶静脉溶栓治疗,观察组在此基础上采用静脉滴注丁苯酞治疗,两组均持续治疗14 d。对比两组患者的神经功能、临床疗效、凝血指标、日常生活活动能力及不良反应发生情况。结果观察组的临床总有效率为93.33%,高于对照组的77.78%,差异有统计学意义(P<0.05)。观察组治疗后的凝血酶时间、活化部分凝血活酶时间、凝血酶原时间均长于对照组,纤维蛋白原水平低于对照组,组间差异有统计学意义(P<0.05)。观察组治疗后的美国国立卫生研究院卒中量表评分为(6.57±1.55)分,低于对照组的(9.23±1.44)分,日常生活活动能力量表评分为(77.74±4.11)分,高于对照组的(68.37±3.74)分,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论急性脑梗死溶栓后患者接受丁苯酞辅助治疗,能明显改善其凝血功能及神经功能,提高日常生活能力,且安全性高。
Objective To investigate the effect of butylphthalein adjuvant therapy on patients with acute cerebral infarction after thrombolysis.Methods The clinical data of 90 patients with acute cerebral infarction admitted to Jinan Third People's Hospital from January to December 2022 were retrospectively analyzed,and they were divided into an observation group(n=45)and a control group(n=45)according to different treatment methods.The control group was treated with intravenous thrombolytic therapy of alteplase,and the observation group was treated with intravenous infusion of butylphthalein.Both groups were treated for 14 days.The neurological function,clinical efficacy,coagulation indexes,activities of daily living and adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 93.33%,higher than 77.78%of the control group,the difference was statistically significant(P<0.05).After treatment,the thrombin time,activated partial thrombin time and prothrombin time in the observation group were longer than those in the control group,and fibrinogen level was lower than that in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the National Institutes of Health stroke scale score in the observation group was(6.57±1.55)points,lower than(9.23±1.44)points in the control group,and the activity of daily living score was(77.74±4.11)points,higher than(68.37±3.74)points in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion After thrombolysis,the patients with acute cerebral infarction received the adjuvant treatment of butylphthalein can significantly improve the coagulation function and neurological function,improve the ability of daily life,and have high safety.
作者
秦瑶
吕仁广
陈刚
QIN Yao;LYU Renguang;CHEN Gang(2nd Department of Neurology,Jinan Third People's Hospital,Jinan Shandong,250132,China;Department of Urology,Jinan Seventh People's Hospital,Jinan Shandong,250101,China)
出处
《反射疗法与康复医学》
2023年第9期126-128,135,共4页
Reflexology And Rehabilitation Medicine
关键词
急性脑梗死
丁苯酞
阿替普酶
静脉溶栓
神经功能
凝血指标
日常生活活动能力
Acute cerebral infarction
Butylphthalide
Ateplase
Intravenous thrombolysis
Neurological function
Coagula-tion indexes
Activities of daily living
作者简介
秦瑶(1987-),女,山东泰安人,本科,主治医师,研究方向:神经内科;通信作者:吕仁广(1985-),男,山东济南人,本科,副主任医师,研究方向:老年泌尿外科,邮箱:413594193@qq.com;通信作者:陈刚(1985-),男,山东日照人,硕士研究生,主治医师,研究方向:老年泌尿外科,邮箱:woaihao864@163.com。
