摘要
近年来,对于脓毒症发病机制和治疗的相关研究已经取得了令人瞩目的成绩,但其发病率和病死率仍居高不下。脓毒症的具体发病机制异常复杂,虽然经过学者们多年的研究,但仍有很多问题尚未得到很好地解答。免疫共抑制分子在脓毒症免疫细胞活化和增殖等过程发挥至关重要的作用。本文主要归纳、总结并分析程序性死亡受体-1(PD-1)、程序性死亡受体配体1(PD-L1)、细胞毒性T淋巴细胞抗原4(CTLA-4)、B7同源物3(B7-H3)等共抑制分子在脓毒症免疫功能紊乱中作用的研究现状,旨在为脓毒症诊疗的理论研究和临床实践提供帮助。
In recent years,remarkable achievements have been made in the research on the pathogenesis and treatment of sepsis,but its morbidity and mortality remain high.The specific pathogenesis of sepsis is extremely complex.Although scholars have studied it for many years,there are still many questions that have not been well answered.Negative costimulatory molecules play an important role in the activation and proliferation of immune cells in sepsis.This article mainly summarized and analyzed the research status of the role of negative costimulatory molecules such as programmed death-1(PD-1),programmed death-ligand 1(PD-L1),cytotoxic T lymphocyte associated antigen-4(CTLA-4),and B7 homolog 3(B7-H3)in sepsis immune dysfunction,in order to provide help for theoretical research and clinical practice of sepsis diagnosis and treatment.
作者
邹佳俊
沈梦雯
朱亮
傅育情
孙旗
褚梦瑶
钱风华
钱义明
Zou Jiajun;Shen Mengwen;Zhu Liang;Fu Yuqing;Sun Qi;Chu Mengyao;Qian Fenghua;Qian Yiming(Department of Emergency Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2022年第6期765-768,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
上海市医药卫生科研项目[ZY(2018-2020)-FWTX-7001]
上海市进一步加快中医药事业发展3年行动计划项目[ZY(2021-2023)-0102]
关键词
脓毒症
免疫功能紊乱
共抑制分子
Sepsis
Immune dysfunction
Negative costimulatory molecules
作者简介
通信作者:钱义明,Email:qianym2004@163.com
