摘要
The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis.
基金
Supported by the National Natural Science Foundation of China,No. 81970541,No. 31960151,No. 81660099 and No. 81660412。
作者简介
Jian-Hong Ding,ORCID number:0000-0003-0877-3879;Zhe Jin,ORCID number:0000-0002-9556-0056;Xiao-Xu Yang,ORCID number:0000-0002-6261-9867;Xiao-Xu Lou,ORCID number:0000-0001-9133-3879;Wei-Xi Shan,ORCID number:0000-0002-7455-6912;Yan-Xia Hu,ORCID number:0000-0002-7470-7063;Qian Du,ORCID number:0000-0001-7056-5208;Qiu-Shi Liao,ORCID number:0000-0002-5555-2203;Rui Xie,ORCID number:0000-0003-3643-3388;Corresponding author:Jing-Yu Xu,PhD,Professor,Department of Gastroenterology,Affiliated Hospital to Zunyi Medical University,No.149 Dalian Road,Huichuan District,Zunyi 563003,Guizhou Province,China.E-mail:xujingyu_gzzy@126.com,ORCID number:0000-0002-0545-0444.
