摘要
目的探讨乳腺浸润性导管癌(IDC)超声声像图特征与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)及Ki-67表达的相关性。方法选取自2018年1月至2021年12月北部战区总医院收治的136例IDC患者为研究对象。所有患者均行常规超声及超声造影检查,分析声像图特征及其与ER、PR、HER-2、Ki-67间的关系。结果直径≥2 cm、纵横比>1、有毛刺、有晕环、有微钙化、后方回声衰减、高增强、晚消散肿物的ER高表达占比分别高于直径<2 cm、纵横比≤1、无毛刺、无晕环、无微钙化、后方回声无衰减、低增强、早消散肿物,差异有统计学意义(P<0.05)。直径≥2 cm、纵横比>1、有毛刺、有微钙化、早增强、晚消散肿物的PR高表达占比分别高于直径<2 cm、纵横比≤1、无毛刺、无微钙化、晚增强、早消散肿物,差异有统计学意义(P<0.05)。直径<2 cm、纵横比≤1、形态规则、有微钙化、早增强、高增强、晚消散肿物的HER-2高表达占比分别高于直径≥2 cm、纵横比>1、形态不规则、无微钙化、晚增强、低增强、早消散肿物,差异有统计学意义(P<0.05)。直径<2 cm、晚增强肿物的Ki-67高表达占比分别高于直径≥2 cm、早增强的肿物,差异有统计学意义(P<0.05)。结论IDC患者超声声像图特征及造影表现与分子生物学ER、PR、HER-2、Ki-67高表达情况有密切相关性,各指标相结合可以为乳腺肿瘤的早期诊断、早期治疗提供重要信息。
Objective To investigate the correlation between the ultrasonographic features of invasive ductal carcinoma(IDC)and the expressions of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2)and Ki-67.Methods A total of 136 IDC patients admitted to General Hospital of Northern Theater Command from January 2018 to December 2021 were selected as the research subjects.All patients underwent conventional ultrasound and contrast-enhanced ultrasound examination to analyze the characteristics of the sonogram and its relationship with ER,PR,HER-2 and Ki-67.Results Diameter 2 centimeters or more,aspect ratio more than 1,the burr,haloes,microcalcification,rear echo attenuation,enhance,late to dissipate the mass of high ER expression ratios were higher than the diameter lower than 2 centimeters,aspect ratio 1 or less,no burr,no dizzy ring,microcalcification,rear echo attenuation,low enhancement,early to dissipate the mass,the difference was statistically significant(P<0.05).The proportion of high expression of PR in mass with diameter 2 centimeters or more,aspect ratio more than 1,burr,microcalcification,early enhancement and late dissipation was higher than that in mass with diameter lower than 2 centimeters,aspect ratio 1 or less,no burr,no microcalcification,late enhancement and early dissipation,respectively,with statistical significance(P<0.05).The proportion of high expression of HER-2 in tumors with diameter lower than 2 centimeters,aspect ratio 1 or less,regular shape,microcalcification,early enhancement,high enhancement,and late dissipation was higher than those with diameter 2 centimeters or more,aspect ratio more than 1,irregular shape,no microcalcification,late enhancement,low enhancement,and early dissipation,with statistical significance(P<0.05).The proportion of Ki-67 expression in tumors with diameter lower than 2 centimeters and late enhancement was higher than those with diameter 2 centimeters or more and early enhancement,respectively,with statistical significance(P<0.05).Conclusion Ultrasonographic characteristics and contrast performance of IDC patients are closely correlated with the high expression of ER,PR,HER-2 and Ki-67 in molecular biology.The combination of these indicators can provide important information for the early diagnosis and treatment of breast tumors.
作者
于馨
曹军英
金壮
蒋南
高越
里子彧
YU Xin;CAO Jun-ying;JIN Zhuang;JIANG Nan;GAO Yue;LI Zi-yu(Department of Ultrasound Diagnosis,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《临床军医杂志》
CAS
2022年第7期666-669,共4页
Clinical Journal of Medical Officers
基金
2020年度辽宁省重点研发计划项目(2020JH2/10300122)
作者简介
第一作者:于馨(1982-),女,黑龙江尚志人,主治医师;通信作者:曹军英,E-mail:shenzongchaosheng@163.com
