摘要
目的探究消肿散结汤结合紫杉醇化疗方案对乳腺癌患者临床疗效、肿瘤标志物及复发率影响。方法研究纳入93例晚期乳腺癌患者,均由该院2017年1月—2019年1月收治,采取随机数字表法将患者分为两组,对照组患者(46例)采取以紫杉醇化疗方案治疗,观察组患者(47例)在对照组治疗基础上联合消肿散结汤治疗,比较两组患者近期疗效、治疗前后患者中医症状积分变化、肿瘤标志物指标变化、T淋巴细胞亚群(CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))指标变化、不良反应及患者1年肿瘤复发率。结果较对照组(47.83%,22/46),观察组总有效率(68.09%,32/47)更高,P<0.05;治疗前,两组患者中医症状总积分、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)水平变化、CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)指标比较,P>0.05,治疗后各组患者中医症状总积分、CEA、CA125、CA153、CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)等指标均改善,观察组患者治疗后中医症状总积分、CEA、CA125、CA153、CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+)等指标均优于对照组,P<0.05;观察组患者治疗不良反应主要为胃肠道反应、肝肾功能异常、骨髓抑制、脱发、皮疹、其他等,略少于对照组,但P>0.05,经处理患者不良反应可缓解;观察组患者1年肿瘤复发率(0.00%)低于对照组(10.87%,5/46),P<0.05。结论消肿散结汤结合紫杉醇化疗方案治疗乳腺癌效果良好,患者恢复较好,免疫功能一定程度提升,值得深入研究。
Objective To explore the effect of Xiaozhong Sanjie Decoction(消肿散结汤)combined with paclitaxel chemotherapy regimen on the clinical efficacy,tumor markers and recurrence rate of breast cancer patients.Methods A total of 93 patients with advanced breast cancer in our hospital from January 2017 to January 2019 were analyzed.By taking a random number table method,the patients were divided into two groups.The control group′s patients(46 cases)were treated with paclitaxel chemotherapy regimens and the observation group′s patients(47 cases)added Xiaozhong Sanjie Decoction on the basis of the treatment of the control group.Two groups′near future curative effect and TCM symptoms score changes of the patients before and after treatment were compared.The tumor markers index change and T lymphocyte subsets(CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)),adverse reactions and 1-year tumor recurrence were observed.Results Compared with that of the control group(47.83%,22/46),the total effective rate in the observation group(68.09%,32/47)was higher(P<0.05).Before treatment,changes in the total score of TCM symptoms,CEA,CA125,CA153,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)and other indicators were not significant between the two groups.After treatment,the total score of TCM symptoms,CEA,CA125,CA153,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)and other indicators were all improved.After treatment,the total score of TCM symptoms,CEA,CA125,CA153,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+)and other indicators in the observation group were all better than those in the control group(P<0.05).The adverse reactions of the patients in the observation group were mainly gastrointestinal reactions,abnormal liver and kidney functions,bone marrow suppression,alopecia,skin rash and so on,slightly less than those in the control group,but there was no significance(P>0.05).The adverse reactions of the patients could be alleviated after treatment.The 1-year tumor recurrence rate in the observation group(0.00%)was lower than that in the control group(10.87%,5/46)(P<0.05).Conclusion Combined with paclitaxel chemotherapy regimen,Xiaozhong Sanjie Decoction has a good effect on breast cancer,with better recovery and improved immune function to some extent.It is worthy of in-depth study.
作者
朱玲
丁美钱
ZHU Ling;DING Meiqian(Department of Tumor Radiotherapy,Lu'an Hospital of Traditional Chinese Medicine,Lu'an 237006,Anhui,China)
出处
《辽宁中医杂志》
CAS
2021年第8期133-136,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
安徽省卫生计生委中医药科研项目(2016zy43)
关键词
乳腺癌
紫杉醇
消肿散结汤
疗效
肿瘤标志物
复发率
breast cancer
taxol
Xiaozhong Sanjie Decoction(消肿散结汤)
curative effect
tumor markers
recurrence rate
作者简介
朱玲(1985-),女,主管护师,学士,研究方向:肿瘤内科。
