摘要
目的通过数据挖掘探索系统性红斑狼疮肺间质病变的中医证候特点。方法采集101例系统性红斑狼疮肺间质病变患者的四诊信息,把每个症状作为一个统计变量,有则赋值1、无则赋值0,计算其频次、频率,对主要症状通过因子分析提取出公因子,然后以公因子作为变量进行聚类分析。结果频数在前10的症状为:少气懒言(75.25%),不寐(75.25%),烦躁(74.26%),气短(71.29%),胸闷(68.32%),咳嗽(59.40%),心悸(57.43%),腰膝酸软(56.43%),动则喘甚(52.47%),咯痰(50.49%)。一共提取公因子13项,总贡献率累计72.898%。最后通过聚类分析得出系统性红斑狼疮肺间质病变的中医辨证为4型,分别为阴虚内热证、湿热阻络证、肾气亏虚证、肺脾气虚证。结论系统性红斑狼疮肺间质病变可分为4型,但临床时需结合患者的性别、并发症、年龄等因素具体论治。
Objective To explore the characteristics of traditional Chinese medicine(TCM)syndrome of systemic lupus erythematosus-associated interstitial lung disease by data mining.Methods The symptom information of 101 patients with systemic lupus erythematosus-associated interstitial lung disease was collected.Each symptom was used as a statistical variable,assigning value 1 or 0 for“with”or“without”a symptom.The frequency and frequency rate of each symptom were calculated.The factor analysis was performed on the main symptoms and common factors were extracted.Clustering analysis was performed using the common factor as a variable.Results The top 10 symptoms were lack of Qi and no desire to speak(75.25%)sleeplessness(75.25%),irritability(74.26%),shortness of breath(71.29%),chest tightness(68.32%),cough(59.40%),palpitations(57.43%),weakness and soreness of waist and knees(56.43%),wheezing when moving(52.47%)and expectoration(50.49%).A total of 13 common factors were extracted.The total contribution rate was 72.898%.The clustering analysis obtained 4 types of syndromes of systemic lupus erythematosus-associated interstitial lung disease including internal heat due to Yin deficiency syndrome,syndrome of dampness-heat blocking collaterals,kidney Qi deficiency syndrome and Qi deficiency of lung and spleen syndrome.Conclusion The main TCM syndrome differentiation pattern of systemic lupus erythematosus-associated interstitial lung disease can be divided into 4 types,but the clinical syndrome should be combined with the specific treatment of the patients′disease course,age,physical constitution and other factors.
作者
赵志娜
李桓
李松伟
ZHAO Zhina;LI Huan;LI Songwei(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;Henan Hospital of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《辽宁中医杂志》
CAS
2022年第7期20-23,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81874465)
关键词
系统性红斑狼疮肺间质病变
证候分类
因子分析
聚类分析
systemic lupus erythematosus-associated interstitial lung disease
classification of syndromes
factor analysis
clustering analysis
作者简介
赵志娜(1993-),女,河南洛阳人,住院医师,硕士,研究方向:中医药防治风湿免疫疾病;通讯作者:李松伟(1972-),男,河南长葛人,主任医师,博士研究生导师,博士,研究方向:中医药防治风湿免疫疾病,E-mail:ywzsy0812@126.com。
