“清肺平喘、祛风解痉”法联合西药治疗支气管哮喘急性发作(热哮证)临床疗效及对血清趋化因子影响被引量：10

Effect of “Clearing Lung-Heat and Relieving Asthma,Dispelling Pathogenic Wind for Resolving Convulsion” Therapy Combined with Western Medicine on Acute Bronchial Asthma with Syndrome of Heat Wheezing and Influence on Serum Chemokines

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摘要目的观察"清肺平喘、祛风解痉"法联合西药治疗支气管哮喘急性发作(热哮证)患者的临床疗效及对血清趋化因子的影响。方法选取2018年10月—2020年6月收治的96例支气管哮喘急性发作(热哮证)作为研究对象,遵循随机、平行对照临床试验设计原则分为对照组和观察组,每组各48例。对照组根据病情严重程度属于轻度者予布地奈德福莫特罗粉吸入剂,属于中度者联合孟鲁司特钠片;观察组则在对照组基础上给予"清肺平喘、祛风解痉"中药复方。两组疗程均为4周。记录两组患者治疗前后的中医症状体征量化评分、哮喘控制测试(ACT)评分,检测两组患者治疗前后的用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、呼气流量峰值(PEF)、呼出气一氧化氮(FeNO)以及血清趋化因子配体19(CCL19)、CCL21水平变化情况。结果观察组临床有效率(93.75%)明显高于对照组(75.00%),差异具有统计学意义(P<0.05)。治疗后两组患者的中医症状体征量化评分、FeNO与血清CCL19、CCL21水平较治疗前显著降低,ACT评分、FVC、FEV1、PEF较治疗前显著提升,且观察组对于上述指标的改善作用显著优于对照组,差异具有统计学意义(P<0.05)。结论"清肺平喘、祛风解痉"法联合西药治疗支气管哮喘急性发作(热哮证)患者疗效确切,可有效缓解临床症状,改善肺通气功能,降低气道FeNO水平,抑制气道炎症水平,控制病情进展。 Objective To observe the clinical efficacy of“clearing lung-heat and relieving asthma,dispelling pathogenic wind for resolving convulsion”therapy combined with Western medicine on acute bronchial asthma with syndrome of heat wheezing and influence on serum chemokines.Methods 96 patients of acute bronchial asthma with syndrome of heat wheezing in the Benxi hospital of traditional Chinese medicine from October 2018 to June 2020 were randomly divided into the observation group and the control group,48 cases in each group.Patients in the mild control group were treated with symbicort turbuhaler,while in the moderate control group combined with montelukast sodium tablets.Patients in the observation group were treated with compound prescription of“clearing lung-heat and relieving asthma,dispelling pathogenic wind for resolving convulsion”on the basis of the control group.Four weeks was a treatment course.The TCM syndrome and sign score and asthma control test(ACT)score was recorded before and after treatment between two groups.Forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),fractional exhaled nitric oxide(FeNO)and serum chemokine ligand 19(CCL19),CCL21 levels were tested before and after treatment between two groups.Results The total effective rate of the observation group(93.75%)was significantly higher than the control group(75.00%)(P<0.05).After treatment,the TCM syndrome and sign score,FeNO,serum CCL19 and CCL21 levels in the two groups were lower significantly compared with those before treatment;ACT score,FVC,FEV1 and PEF in the two groups were higher significantly compared with those before treatment.And the improvement effect trend in the observation group was better than the control group(P<0.05).Conclusion“Clearing lung-heat and relieving asthma,dispelling pathogenic wind for resolving convulsion”therapy combined with Western medicine on acute bronchial asthma with syndrome of heat wheezing has definite curative effect,can effectively relieve clinical symptoms,improve lung ventilation function,reduce the level of FeNO,inhibit airway inflammation level,and control the progress of the disease.

作者李红华 LI Honghua(Benxi Hospital of Traditional Chinese Medicine,Benxi 117000,Liaoning,China)

机构地区本溪市中医院

出处《辽宁中医药大学学报》 CAS 2021年第8期130-134,共5页 Journal of Liaoning University of Traditional Chinese Medicine

基金沈阳市中青年创新人才项目(RC200156)

关键词清肺平喘祛风解痉支气管哮喘热哮证趋化因子 clearing lung-heat and relieving asthma dispelling pathogenic wind for resolving convulsion bronchial asthma syndrome of heat wheezing chemokine

分类号 R562.25 [医药卫生—呼吸系统]

作者简介李红华(1984-),女,辽宁本溪人,副主任中医师,硕士,研究方向:中医治疗呼吸系统疾病。