摘要
目的:评价阴茎生物震感阈值检测下,精准定位阴茎头敏感区域后,在敏感区域涂抹5%利多卡因乳膏治疗原发性早泄的有效性和安全性。方法:本研究纳入了80例在门诊中被确诊阴茎高敏感性早泄的患者,随机分为两组。第一组(40例),按需给与5%的利多卡因乳膏1 ml,环形均匀涂抹于阴茎头,未指导患者进行精准的阴茎头涂抹,持续4周。第二组(40例),进行阴茎生物震动阈值检测,探明阴茎头震动阈值较低的位点,并指导患者在阴茎头的敏感位点涂抹5%的利多卡因乳膏1 ml,持续4周。2组患者均在计划性交前20 min局部或均匀涂抹利多卡因乳膏于阴茎头,涂抹后10 min洗去,用治疗前后的阴道内射精潜伏期(IELTs),并结合阴阿拉伯早泄指数以及IIEF-5评分对治疗前后的疗效和不良反应进行评估。结果:治疗后,两组的IELTs均较治疗前明显好转(P<0.05),而精准涂抹组的阿拉伯早泄评分及IIEF-5评分均较均匀涂抹组高(P<0.05)。结论:本研究推断,根据阴茎头震动阈值涂抹利多卡因,与传统使用表面麻醉剂的方法相比,疗效肯定,且不良事件报告更少,值得临床推广。
Objective:This study aimed to evaluate the efficacy and safety of applying 5%lidocaine cream to the sensitive area of the glans penis after its precise localization under the penile biological vibration threshold test for the treatment of primary premature ejaculation.Methods:Eighty patients diagnosed with primary premature ejaculation in an outpatient setting were included in this study.They were randomly scored into two groups.Group 1(n=40)was given 1 ml of 5%lidocaine cream on demand.They were instructed to apply the lidocaine cream evenly in a circular pattern to the glans penis without precise application to the sensitive area of the glans penis.The treatment lasted for a total of 4 weeks.Group 2(n=40)had a penile biological vibration threshold test performed to detect loci with a lower threshold.They were instructed to apply 1 ml of 5%lidocaine cream to the sensitive loci on the glans penis for 4 weeks.Lidocaine cream was applied topically or uniformly to the glans penis 20 minutes before planned intercourse in both groups.The efficacy and side effects before and after treatment were evaluated by the intravaginal ejaculation latency(IELTs)before and after treatment,combined with the Arabic Index of Premature Ejaculation and IIEF-5 score.Results:After treatment,IELTs in both groups were significantly improved compared with those before treatment(P<0.05);The Arab premature ejaculation index and IIEF-5 score of the precise smear group are higher than those of the uniform smear group(P<0.05).Conclusion:This study infers that applying lidocaine according to the threshold of penile and glans vibration has a positive effect and fewer adverse event reports compared with the traditional method of using surface anesthetics,which is worthy of clinical promotion.
作者
石天昊
符宇立
张琪
黄文杰
吕伯东
SHI Tian-hao;FU Yu-li;ZHANG Qi;HUANG Wen-jie;LÜ Bo-dong(The First Affiliated Hospital Zhejiang University School of Medicine Liangzhu Branch,Hangzhou,Zhejiang 31110,China;The Second School of Clinical Medicine,Zhejiang University of Chinese Medicine,Hangzhou,Zhejiang 310053,China;Department of Urology and Andrology,The Second Hospital Affiliated to Zhejiang University,Hangzhou,Zhejiang 310005,China;Zhejiang Province Key Laboratory of Traditional Chinese Medicine(Laboratory of Andrology),Hangzhou,Zhejiang 310053,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2023年第10期888-893,共6页
National Journal of Andrology
基金
国家自然科学基金面上项目(82074433)
国家临床重点专科项目(ZJ1101WK023)
浙江省自然科学基金(LY18H05004)
关键词
阴茎高敏感性早泄
阿拉伯早泄指数
生物震感阈值
利多卡因
primary premature ejaculation
Arabic Premature Ejaculation Index
penile vibration threshold
Lidocaine
作者简介
石天昊(1997-),男,浙江杭州市人,硕士研究生,从事泌尿外科及男科基础与临床研究。Email:510056790@qq.com;通讯作者:吕伯东,Email:lbd168@126.com
