摘要
目的:观察使用吴茱萸贴敷涌泉穴治疗肿瘤相关性失眠(cancer-related insomia,CRI)的疗效。方法:将我科80例中晚期癌症合并失眠患者随机分成两组,治疗组(40例)予吴茱萸贴敷涌泉穴,对照组(40例)予艾司唑仑片治疗。1个疗程7 d,治疗4个疗程。治疗前后采用匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分进行睡眠质量评估,采用EORTC QLQ-C30(V3)进行生活质量评分,同时测定治疗前和治疗4个疗程后血清淋巴细胞亚群。结果:(1)PSQI评分:治疗组和对照组治疗1个疗程后和4个疗程后的PSQI评分与治疗前相比均明显下降,差异有统计学意义(P<0.05);治疗4个疗程后,治疗组的PSQI评分较对照组显著下降,差异有统计学意义(P<0.05)。(2)治疗组的生活质量评分无论是在治疗1个疗程后还是治疗4个疗程后,与治疗前相比均有明显上升,且均比对照组升高,差异有统计学意义(P<0.05)。(3)淋巴细胞亚群分析显示:与治疗前相比,治疗组CD3+和CD4+细胞计数及CD4+/CD8+细胞比例均明显升高,差异有统计学意义(P<0.05),对照组没有显著差异(P>0.05)。结论:吴茱萸贴敷涌泉穴可显著改善中晚期癌症患者的失眠症状,还可以提高肿瘤相关性失眠患者的生活质量和以T淋巴细胞为代表的免疫指标。随着治疗时间的延长,较艾司唑仑疗效显著,且安全性高。
Objective:To observe the clinical effect of Evodia rutaecarpa applied to Yongquan in the treatment of cancer-related insomnia(CRI).Methods:Total 80 advanced cancer patients with CRI were divided into two groups,40 patients of treat-ment group were Evodia rutaecarpa applied to Yongquan,and the other 40 patients of control group were given eszolam tablets.1 course for 7 days,and 4 consecutive courses were conducted.Pittsburgh sleep quality index score was used to evaluate sleep quality,EORTC QLQ-C30(V3)was used to evaluate quality of life score,and serum lymphocyte subsets were measured before and after 4 courses of treatment.Results:(1)PSQ I score:the PSQI scores of the treatment group and the control group after 1 course of treatment and 4 courses of treatment were significantly lower than those before treatment(P<0.05),and the PSQI scores of the treatment group were significantly lower than those of the control group after 4 courses of treatment(P<0.05).(2)Quality of life(EORTC QLQ-C30)score:the score of quality of life in the treatment group was significantly higher than that before treatment;and it was significantly higher than that in the control group(P<0.05)after either1 course or4 courses of treatment;(3)Lymphocyte subgroup analysis showed that compared with before treatment,the values of CD3+,CD4+and CD4+/CD8+in the treatment group increased significantly(P<0.05),but there was no difference in the control group(P>0.05).Conclusion:Evodia rutaecarpa applied to Yongquan can significantly improve the insomnia symptoms of patients with advanced cancer,and can also improve the quality of life of patients with tumor-associated insomnia and the immune index represented by T lymphocytes.With the prolongation of treatment time,the curative effect is more significant and the safety is higher than that of eszolam.
作者
李灵常
胡灿红
LI Ling-chang;HU Can-hong(Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing,210028)
出处
《内蒙古中医药》
2021年第10期122-124,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
基金
江苏省临床专项(BL2014099)
江苏省领军人才(SLJ0211)
作者简介
李灵常(1984-),女,汉族,江苏南京人,江苏省中西医结合医院副主任中医师,博士,主要从事中西医恶性肿瘤的综合诊治;通讯作者:胡灿红(1978-),女,汉族,湖南宁乡人,江苏省中西医结合医院副主任中医师,博士,主要从事中西医恶性肿瘤的综合诊治。
