摘要
目的探讨不同分级和不同年龄原发性高血压患者RAAS[即肾素(PRA)、血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)]检测的临床意义。方法按照高血压分级标准和年龄,将102例原发性高血压患者均分为3组,其中1级36例、2级42例、3级24例,≤50岁34例、51~65岁38例、>65岁30例,同期选取43名健康人群作为正常对照组。采用电化学发光法测定各组血浆中PRA、AngⅡ、ALD含量,比较分析高血压组、各级高血压组、各年龄组与正常对照组以及各级高血压组之间、各年龄组之间的统计学差异,以评价RAAS三项检测对原发性高血压的临床价值。结果高血压组PRA、AngⅡ、ALD血浆含量分别为(16.68±10.10)pg/mL、(130.31±27.97)pg/mL和(152.15±38.59)pg/mL,均显著高于正常对照组的(7.16±2.32)pg/mL、(91.13±16.94)pg/mL和(116.53±18.12)pg/mL,差异有统计学意义(t=6.883、6.035、4.714,P均<0.01)。各级高血压组和各年龄组PRA、AngⅡ、ALD水平与正常对照组之间差异均有统计学意义(P均<0.01)。各级高血压组血浆样本PRA、AngⅡ、ALD水平比较差异有统计学意义(F=8.046、18.252、14.338,P均<0.01)。3级和2级高血压组血浆样本PRA、AngⅡ、ALD水平与1级高血压组比较显著升高,差异有统计学意义(P均<0.01),3级高血压组血浆PRA、AngⅡ、ALD水平与2级高血压组比较差异有统计学意义(P均<0.05)。各年龄组之间PRA、AngⅡ、ALD水平差异均无统计学意义(P均>0.05)。结论血清PRA、AngⅡ、ALD水平与原发性高血压患者的年龄无关,与高血压级别有关,可作为高血压患者诊断和治疗的重要参考指标。
Objective To investigate the clinical significance of detection of renin(PRA),angiotensinⅡ(AngⅡ)and aldosterone(ALD)in patients with essential hypertension of different grades and ages.Methods 102 patients with essential hypertension were divided into three groups according to the classification standard of hypertension and age respectively,including 36 cases of grade 1,42 cases of grade 2,24 cases of grade 3,34 cases under 50 years old,38 cases between 51 and 65 years old,30 cases over 65 years old.43 health volunteers were selected as normal control group.The levels of PRA,AngⅡand ALD in plasma of each group were determined by ELC Method.The statistical differences among hypertension group,hypertension groups with different grades and ages and normal control group were comparatively analyzed and the statistical differences among groups in different degrees and at different ages were also analyzed.The clinical value of detection of renin,angiotensinⅡand aldosterone in essential hypertension was evaluated.Results The plasma levels of PRA,AngⅡand ALD in hypertension group were(16.68±10.10)pg/mL,(130.31±27.97)pg/mL and(152.15±38.59)pg/mL,respectively,which were significantly higher than those in normal control group[PRA:(7.16±2.32)pg/mL,AngⅡ:(91.13±16.94)pg/mL,ALD:(116.53±18.12)pg/mL]and the differences between groups were statistically significant(t=6.883,6.035,4.714,P<0.01).The levels of PRA,AngⅡand ALD in hypertension groups with different grades and ages were significantly higher than those in normal control group(P<0.01).There were significant differences in the levels of PRA,AngⅡand ALD among hypertension groups of different grades(F=8.046,18.252,14.338,P<0.01).The levels of PRA,AngⅡand ALD of grade 3 and grade 2 hypertension groups were significantly higher than those in grade 1 hypertension group(P<0.01)and there were significant difference between the grade 3 and grade 2 hypertension groups(t=2.103,3.924,2.435,P<0.05).There were no significant differences in the levels of PRA,AngⅡand ALD among groups at different ages(P>0.05).Conclusion The levels of PRA,AngⅡand ALD in plasma were not related to the age of patients with essential hypertension,but related to the grade of hypertension.Plasma PRA,AngⅡand ALD could be used as an important reference index for the diagnosis and treatment of hypertension.
作者
黄星铭
闵晓霞
HUANG Xing ming;MIN Xiao xia(Chengdu Sixth People′s Hospital,Chengdu,Sichuan 610051,China)
出处
《热带医学杂志》
CAS
2019年第6期755-757,共3页
Journal of Tropical Medicine
作者简介
通讯作者:黄星铭(1977-),男,主治医师,主要从事核素治疗和电化学分析,E mail:359707013@qq.com
