摘要
目的探讨美沙拉嗪联合更昔洛韦治疗巨细胞病毒(CMV)感染相关性溃疡性结肠炎的效果。方法选择2015年1月-2020年1月在山西省运城市中心医院接受治疗的80例CMV感染相关性溃疡性结肠炎患者,随机分为试验组(n=41)和对照组(n=39)。对照组给予美沙拉嗪治疗,试验组给予美沙拉嗪联合更昔洛韦治疗。比较两组疗效、红细胞沉降率(ESR)、干扰素γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)表达水平、改良Mayo评分变化及不良反应发生情况。结果治疗后,试验组总有效率明显高于对照组(92.68%vs.71.79%),差异有统计学意义(χ^(2)=6.040,P<0.05)。治疗前,两组血清IFN-γ、ESR、TNF-α、IL-6、CRP水平及改良Mayo评分差异均无统计学意义(P均>0.05)。治疗后,两组血清IFN-γ、ESR、TNF-α、IL-6、CRP水平及改良Mayo评分均下降,且试验组低于对照组,差异均有统计学意义(P均<0.05)。试验组的不良反应总发生率为12.20%,对照组为15.38%,差异无统计学意义(χ^(2)=0.172,P>0.05)。结论在巨细胞病毒感染相关性溃疡性结肠炎中应用美沙拉嗪联合更昔洛韦治疗疗效显著,可有效改善患者IFN-γ、ESR水平。
Objective To study the effect of mesalazine combined with ganciclovir in the treatment of ulcerative colitis associated with cytomegalovirus(CMV)infection.Methods A total of 80 patients with CMV infection associated ulcerative colitis treated in Yuncheng Central Hospital of Shanxi Province from January 2015 to January 2020 were selected and divided into experimental group(n=41)and control group(n=39)by random number table method.The control group was treated with mesalazine,and the experimental group was treated with mesalazine combined with ganciclovir.The efficacy,interferonγ(IFN-γ),erythrocyte sedimentation rate(ESR),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP),modified Mayo score and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the experimental group was significantly higher than that in the control group(92.68%vs.71.79%)(χ^(2)=6.040,P<0.05).Before treatment,there were no significant differences in serum IFN-γ,ESR,TNF-α,IL-6,CRP levels and Mayo score between the two groups(all P>0.05).After treatment,the serum IFN-γ,ESR,TNF-α,IL-6,CRP levels and modified Mayo score were decreased in two groups,and the experimental group was lower than that of the control group,and the differences were significant(all P<0.05).The total incidence of adverse reactions was 12.20%in the experimental group and 15.38%in the control group,with no significant difference(χ^(2)=0.172,P>0.05).Conclusion Mesalazine combined with ganciclovir was effective in the treatment of cytomegalovirus-associated ulcerative colitis,and could effectively improve the levels of IFN-γand ESR.
作者
王燕
吕军宁
邵茉莉
石亚男
王海燕
WANG Yan;LÜ Jun-ning;SHAO Mo-li;SHI Ya-nan;WANG Hai-yan(Department of Gastroenterology,Yuncheng Central Hospital,Yuncheng,Shanxi 044000,China)
出处
《热带医学杂志》
CAS
2023年第1期71-74,共4页
Journal of Tropical Medicine
基金
山西省高等学校科技创新项目(2021L151)
作者简介
王燕(1982-),女,硕士,主治医师,研究方向:溃疡性结肠炎合并巨细胞病毒或EB病毒感染;通信作者:王海燕,E-mail:wina7335831@sina.com
