摘要
目的观察邵氏阳虚哮喘贴联合小剂量沙美特罗替卡松粉吸入剂(舒利迭)治疗肾阳虚型支气管哮喘慢性持续期患者的临床疗效。方法将65例肾阳虚型支气管哮喘慢性持续期患者随机分为治疗组(33例)和对照组(32例)。对照组予常规剂量舒利迭治疗,治疗组予邵氏阳虚哮喘贴及小剂量舒利迭治疗。两组疗程均为42 d,随访6个月,观察临床疗效,比较中医证候积分、哮喘控制水平(ACT)评分、肺功能、呼出气一氧化氮(Fe NO)水平的变化情况。结果①治疗组总有效率87.9%,对照组总有效率81.3%;两组临床疗效比较,治疗组优于对照组(P<0.05)。②治疗后、随访3个月、随访6个月与治疗前组内比较,两组中医证候总积分、次症积分均较治疗前减少(P<0.05)。组间治疗后、随访3个月比较,治疗组中医证候总积分、次症积分少于对照组(P<0.05);组间随访6个月比较,中医证候总积分差异无统计学意义(P>0.05),治疗组次症积分少于对照组(P<0.05)。③治疗后、随访3个月、随访6个月与治疗前组内比较,两组ACT评分均较治疗前升高(P<0.05);各观察时间点组间比较,ACT评分差异无统计学意义(P>0.05)。④随访6个月与治疗前组内比较,两组FEV1、FeNO水平及FEV1/FVC值差异有统计学意义(P<0.05);组间随访6个月比较,FEV1、FeNO水平及FEV1/FVC值差异无统计学意义(P>0.05)。结论邵氏阳虚哮喘贴联合小剂量舒利迭治疗肾阳虚型支气管哮喘慢性持续期患者疗效满意,相较于常规剂量的舒利迭能更好地缓解患者的临床症状,且操作简单,值得临床推广。
Objective To observe the clinical efficacy of Shao’s yang deficiency asthma patch combined with low-dose salmeterol fluticasone in patients with chronic persistent bronchial asthma of kidney-yang deficiency pattern.Methods A total of 65 patients with chronic duration of bronchial asthma of kidney-yang deficiency pattern were randomly divided into the treatment group(33 cases)and the control group(32 cases).The control group was treated with salmeterol fluticasone powder inhalation(Seretide),and the treatment group was treated with Shao’s yang deficiency asthma patch and lowdose Seretide.The course of treatment in both groups was 42 days.Cases were followed for 6 months to observe the clinical effect.The changes in TCM syndrome score,asthma control level(ACT)score,lung function,and exhaled nitric oxide(FeNO)level were compared.Results①The total effective rate in the treatment group was 87.9%,and the total effective rate in the control group was 81.3%.Comparing the clinical efficacy of the two groups,the treatment group showed better clinical efficacy than the control group(P<0.05).②After treatment,follow-up for 3 months,and follow-up for 6 months,the total scores of TCM syndromes and secondary symptoms in both groups decreased compared with those before treatment(P<0.05).After treatment and follow-up for 3 months,the total scores of TCM syndromes and secondary symptoms in the treatment group were lower than those in the control group(P<0.05).There was no significant difference in the total scores of TCM syndromes between two groups after 6-month follow-up(P>0.05),the score of secondary symptoms in the treatment group was lower than that in the control group(P<0.05).③After treatment,follow-up for 3 months,and follow-up for 6 months,the ACT scores of the two groups were higher than those before treatment(P<0.05);there was no significant difference in ACT scores between groups at each observation time point(P>0.05).④The differences in FEV1,FeNO levels,and FEV1/FVC values between the two groups were statistically significant(P<0.05)when compared before the treatment and after 6-month follow-up;Compared after 6-month follow-up between groups,the differences in FEV1,FeNO levels,and FEV1/FVC values were not statistically significant(P>0.05).Conclusion Shao’s yang deficiency asthma patch combined with low-dose Seretide showed satisfactory effects in the treatment of patients with chronic persistent bronchial asthma of kidney yang deficiency pattern.Compared with conventional dosage of Seretide,it can better alleviate the clinical symptoms of patients by simple operation,which is worthy of clinical promotion.
作者
周旎泓
张俊
倪晓青
倪伟
ZHOU Nihong;ZHANG Jun;NI Xiaoqing;NI Wei(Department of Traditional Chinese Medicine,Central Hospital of Songjiang District,Shanghai 201600,China;Respiratory Department,Pudong Branch of Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200126,China;Department of dermatology,Central Hospital of Songjiang District,Shanghai 201600,China)
出处
《上海中医药杂志》
2020年第2期61-64,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市浦东新区卫健委卫生行业科研专项(PW2016E-3).
关键词
支气管哮喘
慢性持续期
邵氏阳虚哮喘贴
舒利迭
中西医结合疗法
bronchial asthma
chronic duration
Shao’s yang deficiency asthma patch
Seretide
integrated traditional Chinese and western medicine
作者简介
周旎泓,女,硕士,住院医师,主要从事中医内科临床工作;通讯作者:倪伟,主任医师,教授。E-mail:2899410597@qq.com
