摘要
肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)作为肿瘤微环境中(tumor microenvironment,TME)的核心调控者在肿瘤的发生发展中具有重要作用。活化的肿瘤相关巨噬细胞可分化出具有不同活化状态和功能的M1型和M2型,M1型肿瘤相关巨噬细胞主要介导抗肿瘤免疫效应,M2型肿瘤相关巨噬细胞促进肿瘤进展。M1/M2型巨噬细胞在特定情况下可以通过“再教育”相互转化。靶向肿瘤相关巨噬细胞成为临床肿瘤治疗的策略,深入探索肿瘤相关巨噬细胞对恶性肿瘤临床预后和治疗的影响成为近年来肿瘤研究的热点。本文就肿瘤相关巨噬细胞与恶性肿瘤的临床预后关系,肿瘤相关巨噬细胞与肿瘤化疗、免疫治疗之间的相互影响等方面进行阐述。
As the core regulator in the tumor microenvironment(TME),tumor-associated macrophages(TAMs)play important roles in the initiation and progressionof malignancies.Activatedmacrophages could be polarized into M1 and M2 phenotype with different activation states and biological functions.In general,M1macrophages foster inflammation response against tumor cells,whereas M2 macrophagestend to exert an immune suppressive phenotype,favoring tumor progression.M1/M2 macrophages could be re-educatedto each other under different TME.Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer,so it is necessary explore the impact of TAMs on the clinical prognosis and treatment of malignant tumors.This article reviewed the relationship between TAMs and the clinical prognosis of malignant tumors,and the interaction between TAMs and tumor chemotherapy and immunotherapy.
作者
朱文婷
陈衍
ZHU Wenting;CHEN Yan(Department of Oncology,the First Affiliated Hospital of Air Force Military Medical University,Shaanxi Xi'an 710032,China)
出处
《现代肿瘤医学》
CAS
北大核心
2022年第3期535-538,共4页
Journal of Modern Oncology
基金
国家自然科学基金面上项目(编号:81872265)。
作者简介
朱文婷(1989—),女,河南博爱人,医师,硕士,主要从事实体肿瘤的基础与临床研究。E-mail:atingting@foxmail.com;通讯作者:陈衍(1977—),女,江苏南京人,副主任医师,副教授,博士,主要从事肿瘤分子靶向治疗及免疫治疗。E-mail:chenyanfmmu@163.com。
