摘要
噬菌体在自然界中分布广泛,是一类感染细菌的病毒总称。同时噬菌体繁殖迅速,对宿主的选择具有非常高的特异性,当其作为细菌感染的抗生素替代疗法时不易让宿主菌形成耐药性。因其严格寄生,其增殖过程除受环境因素(pH、离子强度、温度)影响外,往往还受宿主代谢水平的影响。在外部环境因素中,温度对噬菌体的影响尤为突出,其对噬菌体的活性、稳定性、保藏和进化等都有重要影响。对噬菌体在温度适应性机制研究方面的研究进展进行了总结,重点对噬菌体在温度胁迫下的适应性进化研究进行了整理和归纳,以期为进一步开展噬菌体研究提供帮助。
Bacteriophages are widely distributed in nature.They are a kind of viruses that infect only bacteria.Phages multiply rapidly and have very high specificity for host selection,and are less likely to cause host bacteria to develop resistance when they are used as an antibiotic replacement therapy for bacterial infections.Because it is strictly selected by parasitism,its proliferation process is affected not only by environmental factors(pH,ionic strength,temperature),but also by the host metabolic level.Among the external environmental factors,temperature has an important influence on phage activity,stability,preservation and evolution.In this paper,the research progress of phage in temperature adaptation mechanism was summarized.In addition,the research on phage adaptation evolution under temperatures stress was classified further,and thus will provide help for research in this field.
作者
李金花
白雨凡
马春兰
季秀玲
魏云林
LI Jin-hua;BAI Yu-fan;MA Chun-lan;JI Xiu-ling;WEI Yun-lin(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2022年第1期139-145,共7页
China Biotechnology
基金
国家自然科学基金(31960232)资助项目
关键词
噬菌体
细菌
温度
适应性
进化
Bacteriophage
Bacterial
Temperature
Adaptation
Evolution
作者简介
通讯作者:魏云林,电子信箱:homework18@126.com
