摘要
目的分析钴作业工人班末尿钴水平与工作场所钴及其化合物个体接触水平的关系,探讨其作为生物标志物的可行性。方法采用典型抽样方法,选择某新材料有限公司148名钴作业工人为接触组,以该公司44名无职业性接触钴的人员为对照组。采用电感耦合等离子体-质谱法测定2组人群工作场所空气中钴及其化合物的时间加权平均浓度作为个体接触水平;并采用该方法检测2组人群班前和班末尿钴水平。分析接触组人群班末尿钴水平与工作场所空气中钴及其化合物个体接触水平的线性关系。结果接触组人群钴及其化合物个体接触水平为1.10~131.71μg/m^(3),中位数(M)为12.23μg/m^(3);对照组人群工作场所空气中未检出钴及其化合物。接触组人群班前和班末尿钴水平均高于同时间点对照组(M:1.54 vs 0.56μg/L,8.77 vs 0.83μg/L,P值均<0.01)。接触组人群班末尿钴水平高于其班前尿(M:8.77 vs1.54μg/L,P<0.01),且班末尿钴水平与其钴及其化合物个体接触水平呈正相关(Spearman相关系数=0.86,P<0.01)。接触组人群班末尿钴水平的常用对数值(ŷ)与其钴及其化合物个体接触水平的常用对数值(x)线性回归方程为:ŷ=-0.178+0.988 x(决定系数=0.72;F=374.75,P<0.01;t=-19.36,P<0.01)。结论钴作业工人班末尿钴水平与其职业性钴接触水平存在线性相关;尿钴可作为职业性钴接触的生物标志物。
Objective To analyze the relationship between cobalt level of post-shift urine and individual exposure level of cobalt and its compounds in cobalt exposed workers,and to explore the feasibility of using urine cobalt as a biomarker.Methods A total of 148 occupational cobalt-exposed workers from a new material company were selected as the exposed group,and 44 non-occupational cobalt-exposed workers from the company were selected as the control group using the typical sampling method.The exposure concentration of time weighted average of cobalt and its compounds in the workplace air of the two groups was determined by inductively coupled plasma-mass spectrometry as the individual exposure level.The cobalt levels of pre-shift and post-shift urinary samples of the two groups were detected by this method.The linear relationship between the cobalt level of post-shift urine and the individual exposure level of cobalt and its compounds in the air of the workplace was analyzed.Results The individual exposure level of cobalt and its compounds in the exposed group was 1.10-131.71μg/m^(3) with the median(M)of 12.23μg/m^(3).No cobalt and its compounds were detected in the workplace air in the control group.The cobalt levels of pre-shift and post-shift urines in exposed group were higher than those in the control group at the same time point(M:1.54 vs 0.56μg/L,8.77 vs 0.83μg/L,all P<0.01).The cobalt level of post-shift urine was higher than that in pre-shift urine in the exposed group(M:8.77 vs 1.54μg/L,P<0.01),and it was positively correlated with the individual exposure level of cobalt and its compounds(Spearman correlation coefficient=0.86,P<0.01).After common logarithm conversion,the linear regression equation of the cobalt level of post-shift urine(ŷ)and the common logarithm of individual exposure level of cobalt and its compounds(x)in the exposed group was as follows:ŷ=−0.178+0.988 x(coefficient of determination=0.72;F=374.75,P<0.01;t=-19.36,P<0.01).Conclusion There was a linear correlation between cobalt level of post-shift urine and occupational cobalt exposure level of cobalt exposed workers.Urinary cobalt can be used as a biomarker of occupational cobalt exposure.
作者
罗晓婷
陈雯
董明
吴川
林佐侃
谭剑明
吴邦华
LUO Xiao-ting;CHEN Wen;DONG Ming;WU Chuan;LIN Zuo-kan;TAN Jian-ming;WU Bang-hua(School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,China;不详)
出处
《中国职业医学》
CAS
北大核心
2022年第6期615-620,共6页
China Occupational Medicine
基金
2020年职业健康标准前期研究项目(20210202)
国家临床重点专科建设项目(2011-09)
广东省职业病防治重点实验室(2017B030314152)
广东省职业健康工程技术研究中心(D:2019A069)
广东省化学中毒与核辐射突发事件医学救援应急技术研究中心(2016A020224005)
关键词
钴
化合物
生物标志物
职业接触
尿
相关性
工人
Cobalt
Compounds
Biomarker
Occupational exposure
Urine
Correlation
Worker
作者简介
罗晓婷(1991—),女,在读流行病与卫生统计学硕士研究生,主管医师,主要从事职业卫生检测工作;通讯作者:吴邦华,主任技师,E-mail:wubanghua@163.com;通讯作者:陈雯,教授,E-mail:chenw43@mail.sysu.edu.cn
