摘要
Hyaluronic acid(HA)is a natural polysaccharide that has gained much attention due to its biocompatibility,enzyme degradation capacity and active tumor targeting capacity.Its receptor,CD44,is overexpressed in many kinds of cancers and is associated with tumor progress,infiltration and metastasis.Therefore,many researchers have developed various HA-based drug delivery systems for CD44-mediated tumor targeting.In this review,we systemically overview the basic theory of HA,its receptor and hyaluronidase,then we categorize the studies in HA-based drug delivery systems according to the functions of HA,including tumor-targeting materials,enzyme-sensitive biodegradable modality,pHsensitive component,reduction-sensitive component,and the gel backbone.Finally,the perspective is discussed.
Hyaluronic acid (HA) is a natural polysaccharide that has gained much attention due to its biocompatibility,enzyme degradation capacity and active tumor targeting capacity.Its receptor,CD44,is overexpressed in many kinds of cancers and is associated with tumor progress,infiltration and metastasis.Therefore,many researchers have developed various HA-based drug delivery systems for CD44-mediated tumor targeting.In this review,we systemically overview the basic theory of HA,its receptor and hyaluronidase,then we categorize the studies in HA-based drug delivery systems according to the functions of HA,including tumor-targeting materials,enzyme-sensitive biodegradable modality,pHsensitive component,reduction-sensitive component,and the gel backbone.Finally,the perspective is discussed.
基金
supported by Doctoral Research Startup Fund of the Affiliated Hospital of Southwest Medical University,China(16250)
National Natural Science Foundation of China(81872806 and 31571016)
Young Elite Scientists Sponsorship Program by CAST,China(2017QNRC001)
Luzhou Municipal Government-Southwest Medical University Science and Technology Strategic Cooperation Project,China(2018LZXNYPT02).
作者简介
Corresponding authors:Yan Dai,E-mail addresses:daiyan@swmu.edu.cn,These authors made equal contributions to this work;Corresponding authors:Huile Gao,-mail addresses:gaohuilescu@163.com,gaohuile@scu.edu.cn,These authors made equal contributions to this work.
