摘要
大麻二酚是大麻主要的非精神类活性成分,具有抗癫痫、免疫调节、镇痛、抗氧化、抗惊厥、抗焦虑等作用。近年来研究发现其也具有抑制肿瘤细胞增殖,诱导肿瘤细胞凋亡和自噬,细胞周期阻滞,抗肿瘤细胞侵袭和转移,调节肿瘤微环境、协同化疗药物,减少化疗药物的毒性等作用,但其抗肿瘤作用仍存在争议,开发和应用受到限制,采用微球、纳米脂质体等新给药系统有助于提高大麻二酚的抗肿瘤活性。该文对近年来大麻二酚抗肿瘤的作用机制进行论述,以期为其进一步的研究和应用提供参考。
Cannabidiol is the main non-psychoactive component of Cannabis sativa, which has multiple medicinal activities, such as antiepileptic, immunomodulation, analgesic, antioxidant, anticonvulsant, anti-anxiety and other functions. In recent years, it has been found that cannabidiol can inhibit the proliferation of various tumor cells, induce apoptosis and autophagy of tumor cells, arrest cell cycle, interrupt invasion and metastasis of tumor cells, regulate tumor microenvironment, exert synergistic therapy with other chemotherapeutic drugs, and reduce the toxicity of chemotherapeutic drugs. However, its anti-tumor effect remains controversial and its application is limited. The study of microspheres, nano liposomes and other new drug delivery systems can improve the anti-tumor effect of cannabidiol. In this study, the anti-tumor mechanism and application of cannabidiol were summarized and discussed in order to provide inspirations for its further investigation and application.
作者
谢冉
郝单丽
杨佳颖
贾玲玉
王朋倩
赵钰
陈燕军
赵庆贺
XIE Ran;HAO Dan-li;YANG Jia-ying;JIA Ling-yu;WANG Peng-qian;ZHAO Yu;CHEN Yan-jun;ZHAO Qing-he(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2022年第24期6541-6550,共10页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81974461,22005344)
国家“重大新药创制”科技重大专项(2018ZX09201-011)
北京市自然科学基金项目(2192060)
作者简介
谢冉,博士研究生,主要从事中药药理研究和中药新剂型研究,Tel:(010)84036059,E-mail:xieran9636@163.com;通信作者:赵钰,博士,助理研究员,主要从事纳米药物传递体系研究,E-mail:yzhao1989@icmm.ac.cn;通信作者:陈燕军,博士,研究员,主要从事中药新型给药系统的研究,E-mail:yjchen@icmm.ac.cn;通信作者:赵庆贺,博士,副研究员,主要从事纳米药物传递体系研究,E-mail:qhzhao@icmm.ac.cn
