摘要
Since insulin,a natural peptide composed of 51 amino acids,was first isolated and commercialized in the 1920s,peptide drugs have greatly reshaped our modern drug discovery area^(1).To date,the total number of approved peptide drugs for human use worldwide has exceeded 60^(2).Popular peptide drugs such as liraglutide(Victoza)^(2) and glucagon-like peptide 1(GLP-1)^(3) are the topselling drugs for type 2 diabetes.However,significant hurdles associated with natural peptide sequences as therapeutics,such as metabolic instability and,consequently,have low oral bioavailability and shorter half-life^(4),are still remaining.To overcome the limitations of natural peptides and further optimize their advantages,peptidomimetics emerged as an alternative strategy.
作者简介
Jianfeng Cai,Department of Chemistry,University of South Florida,Tampa,FL 33620,USA,E-mail address:jianfengcai@usf.edu;Lulu Wei,Department of Chemistry,University of South Florida,Tampa,FL 33620,USA,E-mail address:luluwei@usf.edu
