摘要
目的了解长沙地区普通人群泌尿生殖道支原体感染的现状及药敏情况,为临床合理用药提供依据。方法收集并回顾性分析湖南省人民医院1 409例门诊泌尿生殖道感染者的支原体培养鉴定结果及其药物敏感试验结果。结果 1 409例门诊样本中,支原体总阳性率为15.3%(215/1409);其中,解脲脲原体(Uu)和人型支原体(Mh)阳性率为11.5%和6.2%,单独感染Uu、单独感染Mh和混合感染Uu+Mh阳性率分别为9.1%、3.8%和2.4%;女性支原体阳性率为22.3%,明显高于男性的3.3%(χ^2=92.378,P<0.01);药物敏感性较高的为强力霉素、美满霉素和交沙霉素,耐药性较高的有喹诺酮类和罗红霉素;女性感染者对交沙霉素和壮观霉素的敏感性高于男性,对其他药物的敏感性则明显低于男性。单独Uu感染者对各抗菌药物(环丙沙星和壮观霉素除外)的敏感性均高于单独Mh感染者,而混合Uu+Mh感染者则为药物敏感性最低的一组(对大部分药物的敏感性低于40%)。结论长沙地区普通人群泌尿生殖道支原体感染的阳性率总体较低,但耐药问题依然突出,临床用药时可把四环素类药物和交沙霉素纳入首选,同时依据感染者的性别、感染类型等选择适宜药物进行治疗。
Objective To analyze the status of urogenital tract mycoplasma infection and drug susceptibility in Changsha area, and provide basis for clinical rational drug use. Methods The results of mycoplasma culture and drug sensitivity test of 1,409 cases of urogenital tract infection were collected and retrospectively analyzed. Results The total detection rate of mycoplasma was 15.3%(215/1409). The detection rates of Ureaplasma urealyticum(Uu) and Mycoplasma hominis(Mh) were 11.5% and 6.2% respectively. The positive rates of Uu alone, Mh alone, and Uu+Mh infection were 9.1%, 3.8% and 2.4%, respectively. The positive rate of mycoplasma infection in females was 22.3%, which was significantly higher than the 3.3% in males(χ^2=92.378,P<0.01). The drug sensitivity was higher to Doxycycline, Minocycline and Josamycin, while the drug resistance was higher to Quinolones and Roxithromycin. Females were more sensitive to Josamycin and Spectinomycin than males, but their sensitivity to other drugs was significantly lower. The patients infected by Uu alone had higher susceptibility to antimicrobial agents(except Ciprofloxacin and Spectinomycin) than those infected by Mh alone, whereas those infected by Uu+Mh had the lowest sensitivity(the sensitivity to most drugs was less than 40%). Conclusion The positive rate of urogenital tract mycoplasma infection in Hu′nan is not very high, but drug resistance remains a challenge. Clinically, Tetracyclines and Josamycin can be considered as the first choice, and appropriate drugs can be used based on the sex of patient and type of infection.
作者
王宏波
王宇鹏
李皇庆
曾蓉
梁仙志
叶湘漓
WANG Hongbo;WANG Yupeng;LI Huangqing;ZENG Rong;LIANG Xianzhi;YE Xiangli(College of Medicine,Hu′nan Normal University,Changsha,Hu′nan 410013,China;Hu′nan Provincial People′s Hospital,the First Affiliated Hospital of Hunan Normal University,Changsha,Hu′nan 410005,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2020年第2期172-175,179,共5页
Chinese Journal of Microecology
基金
国家自然科学基金(81270291)
国家出国留学基金(201708430158)
湖南省教育厅科学研究项目重点项目(18A028)
湖南省自然科学基金(2016JJ6098)
湖南师范大学博士科研启动项目
湖南师范大学大学生创新性实验项目(2018086).
关键词
泌尿生殖道感染
解脲脲原体
人型支原体
药物敏感试验
Urogenital tract infection
Ureaplasma urealyticum
Mycoplasma hominis
Antimicrobial susceptibility test
作者简介
王宏波(1989-),女,硕士,从事病原生物学研究,E-mail:wanghongbo_bobo@qq.com;通信作者:叶湘漓(1970-),男,教授,硕士生导师,E-mail:ye_xiangli@hunnu.edu.cn
