摘要
目的分析缬沙坦或贝那普利联合阿托伐他汀治疗慢性心力衰竭的临床效果及安全性。方法将2019年2月至2020年2月我院慢性心力衰竭患者60例分为对照组与观察组,各30例。对照组给予贝那普利与阿托伐他汀联合治疗,观察组接受缬沙坦与阿托伐他汀联合治疗。评估患者的血清炎性因子、心功能指标、临床疗效与不良反应。结果治疗后,对照组患者的血清炎性因子大幅超过观察组患者,差异具有统计学意义(P<0.05);观察组患者的心功能指标显著优于对照组患者,差异具有统计学意义(P<0.05)。观察组患者的治疗总有效率为90.00%,略高于对照组患者的86.67%,两两差异不具有统计学意义(P>0.05)。对照组与观察组患者的临床不良反应发生率分别为13.33%、10.00%,两两差异不具有统计学意义(P>0.05)。结论相比于贝那普利联合阿托伐他汀,缬沙坦联合阿托伐他汀治疗慢性心力衰竭,对减轻患者炎性反应的效果更佳,从而更好地改善患者的心功能;两种联合用药方案的临床效果及安全性相当。
Objective To analyze the clinical effect and safety of valsartan or benazepril combined with atorvastatin in the treatment of chronic cardiac exhaustion.Methods 60 patients with chronic heart failure in our hospital from February 2019 to February 2020 were divided into control group and observation group,30 cases in each group.The control group was given benazepril combined with atorvastatin,while the observation group was treated with valsartan and atorvastatin.The serum inflammatory factors,cardiac function indexes,clinical efficacy and adverse reactions were evaluated.Results After treatment,the serum inflammatory factors of the control group were significantly higher than those of the observation group,the difference was statistically significant(P<0.05);the cardiac function index of the observation group was significantly better than that of the control group,there was statistical significance(P<0.05).The total effective rate of the observation group was 90.00%,slightly higher than 86.67%of the control group,there was no statistical significance(P>0.05).The incidence of clinical adverse reactions in the observation group and the control group were 10.00%and 13.33%,respectively,there was no statistical significance(P>0.05).Conclusion Compared with benazepril combined with atorvastatin,valsartan combined with atorvastatin in the treatment of chronic cardiac exhaustion has a better effect on reducing the inflammatory reaction of patients,so as to better improve the cardiac function of patients;the clinical effect and safety of the two combined medication schemes are similar.
作者
吴土明
李华德
WU Tu-ming;LI Hua-de(The Second Health Center of Huangpo Town,Wuchuan,Guangdong 524565;Wuchuan People's Hospital,Wuchuan,Guangdong 524500)
出处
《智慧健康》
2021年第11期138-140,共3页
Smart Healthcare
关键词
缬沙坦
贝那普利
阿托伐他汀
慢性心力衰竭
安全性
疗效
心功能
Valsartan
Benazepril
Atorvastatin
Chronic cardiac exhaustion
Safety
Efficacy
Cardiac function
