摘要
目的探讨氟伐他汀对冠心病伴心力衰竭患者心功能指标及血清炎性因子水平的影响。方法选取佳木斯市中心医院收治的冠心病伴心力衰竭患者82例,采用随机综合序贯法分为对照组和观察组各41例。对照组采用常规治疗,观察组在对照组基础上采用氟伐他汀治疗。比较2组心功能指标[左心室射血分数(LVEF)、左心室收缩末内径(LVESD)、左心室舒张末内径(LVEDD)]、血清炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)]水平和疗效。结果治疗后,2组LVEF高于治疗前,LVESD、LVEDD低于治疗前,观察组LVEF高于对照组,LVESD、LVEDD低于对照组(P<0.05);2组hs-CRP、TNF-α、IL-6水平均低于治疗前,观察组hs-CRP、TNF-α、IL-6水平均低于对照组(P<0.05)。观察组总有效率高于对照组(92.68%vs 75.61%,P<0.05)。结论氟伐他汀治疗冠心病伴心力衰竭患者可明显改善心功能,降低炎性因子水平,提升疗效。
Objective To investigate the effects of fluvastatin on cardiac function indexes and levels of serum inflammatory factors in patients with coronary heart disease and heart failure.Methods A total of 82 patients with coronary heart disease and heart failure admitted to our hospital were selected and divided into two groups by random comprehensive sequential method,with 41 patients in each group.The control group received conventional treatment,while the observation group received fluvastatin on the basis of conventional treatment.The cardiac function indicators,levels of serum inflammatory factors and efficacy were compared between the two groups.Results Before treatment,there were no statistically significant differences in the left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),and left ventricular end-diastolic diameter(LVEDD)between observation group and control group[(37.35±6.58)%vs(37.62±5.49)%,(58.52±5.64)mm vs(58.29±5.36)mm,(65.72±6.29)mm vs(65.27±6.58)mm,P>0.05].After treatment,LVEF(46.38±3.65)%in the observation group was higher than that(43.59±4.72)%in the control group,while LVESD(49.25±4.19)mm and LVEDD(50.09±5.28)mm were lower than those[(51.46±3.28)mm,(53.64±5.37)mm]in the control group(P<0.05).After treatment,the hypersensitive C-reactive protein(HS-CRP)(1.05±0.49)mmol/L,tumor necrosis factor(TNF-α)(168.72±45.64)ng/L,and interleuk-6(IL-6)(41.05±12.28)ng/L in the observation group were lower than those[(1.36±0.64)mmol/L,(185.14±41.73)ng/L,(47.29±11.4)ng/L]in the control group.The total effective rate(92.68%)in the observation group was higher than that(75.61%)in the control group(P<0.05).Conclusion Fluvastatin in the treatment of coronary heart disease combined with heart failure can significantly improve the cardiac function of patients,reduce the levels of inflammatory factors and increase the efficacy.
作者
刁中极
DIAO Zhong-ji(Department of Cardiology,The Central Hospital of Jiamusi City,Jiamusi 154002,China)
出处
《中国误诊学杂志》
CAS
2020年第5期193-195,共3页
Chinese Journal of Misdiagnostics
关键词
冠心病
心力衰竭
氟伐他汀
coronary disease
heart failure
fluvastatin
