摘要
目的探讨痰热清注射液联合左氧氟沙星治疗慢性阻塞性肺疾病急性发作(AECOPD)合并肺炎效果及对肺炎严重程度、白细胞介素-6(IL-6)、降钙素原(PCT)、淀粉样蛋白A(SAA)水平影响性。方法选取2019年1月—2020年1月共380例AECOPD合并肺炎急诊留观患者为研究对象,按治疗方案不同分成两组,每组190例。对照组头孢哌酮舒巴坦联合左氧氟沙星治疗,研究组加用痰热清注射液治疗,均治疗2周。观察治疗前、治疗完成后在炎症指标、免疫功能、肺功能指标变化并比较,并总结疗效。结果(1)两组治疗2周后用力肺活量、呼气峰流速、呼气中段流速较治疗前均显著上升(P<0.05),且研究组上升幅度显著高于对照组(P<0.05)。(2)两组治疗2周后IL-6、PCT、SAA、C反应蛋白(CRP)较治疗前均显著降低,淀粉样蛋白P(SAP)较治疗前均显著上升(P<0.05),且研究组IL-6、PCT、SAA、CRP、SAP改善幅度均显著优于对照组(P<0.05)。(3)两组治疗2周后CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)、IgA、IgG、IgM较治疗前均显著上升,CD_(8)^(+)较治疗前均显著下降(P<0.05),且研究组以上免疫功能指标均显著优于对照组(P均<0.05)。(4)对照组治愈率35.26%(67/190)、总有效率83.16%(158/190),研究组治愈率42.63%(81/190)、总有效率91.06%(173/190),研究组治愈率、总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论痰热清注射液联合左氧氟沙星治疗AECOPD合并肺炎能显著抑制炎症反应,改善肺功能,提高机体免疫功能,预后好。
Objective To investigate the effect of Tanreqing Injection(痰热清注射液)combined with levofloxacin on the acute attack of chronic obstructive pulmonary disease(AECOPD)with pneumonia and its influence on the severity of pneumonia,the level of IL-6,PCT and SAA.Methods A total of 380 patients with emergency observation or infusion were selected from January 2019 to January 2020.According to the treatment plan,the patients were divided into two groups,190 cases in each group.The control group was treated with cefoperazone sulbactam combined with levofloxacin,and the study group was treated with Tanreqing Injection for two weeks.The changes of inflammatory index,immune function and pulmonary function index before and after treatment were observed and compared,and the curative effect was summarized.Results①The forced vital capacity,peak expiratory velocity and middle expiratory velocity of the two groups were significantly higher than those before treatment(P<0.05),and the increase range of the study group was significantly higher than that of the control group(P<0.05).②After two weeks of treatment,the levels of IL-6,PCT,SAA and C reactive protein(CRP)were significantly lower than those before treatment,and the levels of amyloid protein P(SAP)was significantly higher than that before treatment(P<0.05),and the improvements of IL-6,PCT,SAA,CRP and SAP in the study group were significantly better than those of the control group(P<0.05).③After two weeks of treatment,the levels of CD_(4)^(+),CD_(4)^(+)/CD_(8)^(+),IgA,IgG and IgM were significantly higher than those before treatment,the level of CD_(8)^(+) was decreased significantly(P<0.05),and the above immune function indexes of the study group were significantly better than those of the control group(P<0.05).④The cure rate and total effective rate of the control group were 35.26%(67/190)and 83.16%(158/190),respectively.The cure rate of the study group was 42.63%(81/190)and the total effective rate was 91.06%(173/190).The cure rate and the total effective rate of the study group were significantly higher than those of the control group and the difference was statistically significant(P<0.05).Conclusion The combination of Tanreqing Injection and levofloxacin in the treatment of AECOPD combined with pneumonia can significantly inhibit the inflammatory response,improve the lung function and the immune function of the body and has a good prognosis.
作者
卢秀英
程新欣
李玉琦
LU Xiuying;CHENG Xinxin;LI Yuqi(Affiliated Hospital of Guizhou Medical University,Guiyang 550001,Guizhou,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第5期51-54,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局名老中医传承工作室建设项目(2014-398)
作者简介
卢秀英(1967-),女,贵州贵阳人,副教授,研究方向:心理干预及疾病预防。
