目的综合描述分析芝罘区恶性肿瘤的流行特征和疾病负担,为芝罘区以及烟台市肿瘤防控提供科学依据,降低疾病负担。方法利用芝罘区疾控中心收集的2010—2020年恶性肿瘤发病和死亡数据,使用发病率、死亡率评估恶性肿瘤发病和死亡水平,利用...目的综合描述分析芝罘区恶性肿瘤的流行特征和疾病负担,为芝罘区以及烟台市肿瘤防控提供科学依据,降低疾病负担。方法利用芝罘区疾控中心收集的2010—2020年恶性肿瘤发病和死亡数据,使用发病率、死亡率评估恶性肿瘤发病和死亡水平,利用世界卫生组织发布的excel模板和DismodⅡ软件计算伤残调整寿命年(disability adjusted life year,DALY)、过早死亡损失寿命年(years of life lost,YLL)和DALY率等疾病负担指标。采用Joinpoint回归模型分析疾病负担变化趋势,并计算出年度变化百分比和年度平均变化百分比。结果2010—2020年芝罘区恶性肿瘤合计的DALY为166192.75人年,DALY率为199.02‰,恶性肿瘤的疾病负担主要来自YLL,占DALY的74.70%。结论芝罘区恶性肿瘤的疾病负担呈上升趋势,相关部门仍需完善恶性肿瘤的登记报告,通过公益宣讲的方式提高人群知识掌握率,加大常见恶性肿瘤的筛查力度,推进癌症早诊早治的进展,减少早逝带来的疾病负担,完善恶性肿瘤的三级预防。展开更多
Limosilactobacillus reuteri is a microbe intricately linked to humans and animal health.A thorough assessment of its safety and potential benefits is imperative prior to its application in human and animals.In this in...Limosilactobacillus reuteri is a microbe intricately linked to humans and animal health.A thorough assessment of its safety and potential benefits is imperative prior to its application in human and animals.In this investigation,we performed a comprehensive analysis encompassing genome sequencing,genomic analysis,and phenotypic characterization of L.reuteri Q35,an exceptionally proficient producer of reuterin.The whole genome sequencing results showed that the complete genome sequence spans 2145158 bp with a GC content of 38.9%and encompasses 2121 genes.Initial identification of antibiotic-resistant genes,virulence factors,and toxin-coding genes in the genome substantiated the strain’s low-risk status.Subsequent tests for antibiotic resistance,acute oral toxicology,and hemolysis further confirmed its elevated safety level.The genome of L.reuteri Q35 was found to contain genes associated with adhesion and stress tolerance.Following exposure to artificial gastric juice and bile salt,the strain exhibited a higher survival rate and demonstrated a strong scavenging ability for hydroxyl free radicals in antioxidant capacity tests.These findings suggested that L.reuteri Q35 possesses unique probiotic properties.Additionally,the genome of strain Q35 harbors three truncated oxaloyl-CoA decarboxylase genes(oxc1,oxc2 and oxc3),overexpression of which resulted in a significant increase in ammonium oxalate degradation from 29.5%to 48.8%.These findings highlight that L.reuteri Q35 exhibits both favorable safety characteristics alongside beneficial properties,making it a promising candidate for treating metabolic disorders such as hyperoxaluria.展开更多
文摘目的综合描述分析芝罘区恶性肿瘤的流行特征和疾病负担,为芝罘区以及烟台市肿瘤防控提供科学依据,降低疾病负担。方法利用芝罘区疾控中心收集的2010—2020年恶性肿瘤发病和死亡数据,使用发病率、死亡率评估恶性肿瘤发病和死亡水平,利用世界卫生组织发布的excel模板和DismodⅡ软件计算伤残调整寿命年(disability adjusted life year,DALY)、过早死亡损失寿命年(years of life lost,YLL)和DALY率等疾病负担指标。采用Joinpoint回归模型分析疾病负担变化趋势,并计算出年度变化百分比和年度平均变化百分比。结果2010—2020年芝罘区恶性肿瘤合计的DALY为166192.75人年,DALY率为199.02‰,恶性肿瘤的疾病负担主要来自YLL,占DALY的74.70%。结论芝罘区恶性肿瘤的疾病负担呈上升趋势,相关部门仍需完善恶性肿瘤的登记报告,通过公益宣讲的方式提高人群知识掌握率,加大常见恶性肿瘤的筛查力度,推进癌症早诊早治的进展,减少早逝带来的疾病负担,完善恶性肿瘤的三级预防。
文摘Limosilactobacillus reuteri is a microbe intricately linked to humans and animal health.A thorough assessment of its safety and potential benefits is imperative prior to its application in human and animals.In this investigation,we performed a comprehensive analysis encompassing genome sequencing,genomic analysis,and phenotypic characterization of L.reuteri Q35,an exceptionally proficient producer of reuterin.The whole genome sequencing results showed that the complete genome sequence spans 2145158 bp with a GC content of 38.9%and encompasses 2121 genes.Initial identification of antibiotic-resistant genes,virulence factors,and toxin-coding genes in the genome substantiated the strain’s low-risk status.Subsequent tests for antibiotic resistance,acute oral toxicology,and hemolysis further confirmed its elevated safety level.The genome of L.reuteri Q35 was found to contain genes associated with adhesion and stress tolerance.Following exposure to artificial gastric juice and bile salt,the strain exhibited a higher survival rate and demonstrated a strong scavenging ability for hydroxyl free radicals in antioxidant capacity tests.These findings suggested that L.reuteri Q35 possesses unique probiotic properties.Additionally,the genome of strain Q35 harbors three truncated oxaloyl-CoA decarboxylase genes(oxc1,oxc2 and oxc3),overexpression of which resulted in a significant increase in ammonium oxalate degradation from 29.5%to 48.8%.These findings highlight that L.reuteri Q35 exhibits both favorable safety characteristics alongside beneficial properties,making it a promising candidate for treating metabolic disorders such as hyperoxaluria.
