This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each...This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each associated with unique plasma parameter fluctuations.Magnetic fluctuations,particularly the disruption of magnetic surface structures caused by sawtooth crashes,may play a significant role in modulating plasma dynamics.Moreover,the crossphase term and coherence between density and velocity fluctuations were found to be key factors in these flux events,with high coherence correlating with peak inward flux.These findings enhance the understanding of fluctuation-induced transport after sawtooth crashes and have implications for plasma confinement in fusion devices.展开更多
This paper introduced a compact high flux polarized neutron beam generator scheme,which used air as the working medium and had low energy consumption.The neutron beam generator adopted a linear three compartment confi...This paper introduced a compact high flux polarized neutron beam generator scheme,which used air as the working medium and had low energy consumption.The neutron beam generator adopted a linear three compartment configuration,sequentially using nitrogen nucleus tandem near range accelerated polarization target spallation nuclear reaction technology,neutron multiplication technology,neutron beam polarization and near range acceleration technology,neutron focusing and shooting control technology.Through design and equivalent verification,it has been proven that the total length of the device does not exceed 5 m,the effective range can reach several hundred kilometers,the neutron flux at the muzzle is not less than 10^(25) n·cm^(-2)·s^(-1),which attenuates to 10^(10) n·cm^(-2)·s^(-1) at a distance of several 100 km,and this flux can effectively strike the target.It can be used as a defensive directed energy weapon with high energy density and has broad application prospects.展开更多
Objective Formononetin(FOR),a traditional Chinese medicine,has been widely used for nerve protection and nerve function rehabilitation after cerebral stroke.However,the role of FOR in autophagic lysosome function in c...Objective Formononetin(FOR),a traditional Chinese medicine,has been widely used for nerve protection and nerve function rehabilitation after cerebral stroke.However,the role of FOR in autophagic lysosome function in cerebral ischemiareperfusion damage has not been investigated.This study aimed to explore whether the therapeutic benefits of FOR were influenced by the regulation of autophagy flux.Methods Male Sprague-Dawley rats were separated into sham,model,and MCAO+FOR(30 mg/kg)groups after undergoing middle cerebral artery occlusion(MCAO)and ischemia-reperfusion(I/R).Then,the brain tissues in the ischemic penumbra were obtained to detect the proteins in autophagic/lysosomal pathway with antibodies of Beclin-1,LC3,SQSTM1/P62,Ubiquitin,LAMP-2,Cathepsin B(CTSB)and Cathepsin D(CTSD)by Western blot and immunofluorescence,respectively.Meanwhile,the therapeutic effectiveness was evaluated by measuring infarct volume,neurological impairments,and neuronal necrosis.Results The findings of this study demonstrate that FOR treatment exhibits a dual effect by enhancing the autophagic activities of Beclin-1 and LC3 in neurons,while simultaneously improving the autophagic clearance function,as evidenced by reinforced lysosomal activities of LAMP-2,CTSB,and CTSD,as well as reduced autophagic accumulation of Ubiquitin and P62 in the MCAO+FOR group compared to the MCAO group.Additionally,7 d of FOR treatment dramatically reduced neurological deficits,infarct volume,and neuronal death caused by cerebral ischemia.Conclusion These findings suggest that the neuroprotective mechanism of FOR therapy in accelerating recovery from ischemic stroke may involve the increase of autophagy flux in the penumbra.展开更多
潜热通量产品的验证与分析对于研究气候变化及能量循环具有重要意义。全球陆表高分辨率蒸散产品(high resolution global lAnd surface evapotranspiration product,Hi-GLASS ET)融合了5种传统蒸散算法,能够生产出较高精度的陆表潜热通...潜热通量产品的验证与分析对于研究气候变化及能量循环具有重要意义。全球陆表高分辨率蒸散产品(high resolution global lAnd surface evapotranspiration product,Hi-GLASS ET)融合了5种传统蒸散算法,能够生产出较高精度的陆表潜热通量产品,但目前没有针对此产品的验证研究。利用Ameriflux通量观测站点的潜热通量观测值与相应的Hi-GLASS陆表潜热通量产品估算值进行对比,获取多组有效验证数据。验证结果显示,所选站点实际观测值与产品估算值的决定系数(R 2)为0.6,均方根误差(RMSE)为34.4 W/m^(2),平均偏差(Bias)为-13.4 W/m^(2),克林-古普塔效率(Kling-Gupta efficiency,KGE)为0.49,Hi-GLASS潜热通量产品具有较高的精度,算法的拟合结果较好;此外,空间分布也表明Hi-GLASS陆表潜热通量产品符合正常的自然规律。由于数据获取的局限性,仅采用了美国地区18个站点数据对产品进行验证,在其他地区仍需进一步验证。展开更多
基金support of these experiments.This work was supported by the National Natural Science Foundation of China(12405268,12175227,11875255,12375226,and 11975231)the National Magnetic Confinement Fusion Science Program of China(2022YFE03060003,2022YFE03100004)+1 种基金the Fundamental Research Funds for the Central Universities(WK2140000016)the China Postdoctoral Science Foundation(2022M723066).
文摘This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each associated with unique plasma parameter fluctuations.Magnetic fluctuations,particularly the disruption of magnetic surface structures caused by sawtooth crashes,may play a significant role in modulating plasma dynamics.Moreover,the crossphase term and coherence between density and velocity fluctuations were found to be key factors in these flux events,with high coherence correlating with peak inward flux.These findings enhance the understanding of fluctuation-induced transport after sawtooth crashes and have implications for plasma confinement in fusion devices.
基金sponsored by National Natural Science Foundation of China (Grant No. 12405215)
文摘This paper introduced a compact high flux polarized neutron beam generator scheme,which used air as the working medium and had low energy consumption.The neutron beam generator adopted a linear three compartment configuration,sequentially using nitrogen nucleus tandem near range accelerated polarization target spallation nuclear reaction technology,neutron multiplication technology,neutron beam polarization and near range acceleration technology,neutron focusing and shooting control technology.Through design and equivalent verification,it has been proven that the total length of the device does not exceed 5 m,the effective range can reach several hundred kilometers,the neutron flux at the muzzle is not less than 10^(25) n·cm^(-2)·s^(-1),which attenuates to 10^(10) n·cm^(-2)·s^(-1) at a distance of several 100 km,and this flux can effectively strike the target.It can be used as a defensive directed energy weapon with high energy density and has broad application prospects.
文摘Objective Formononetin(FOR),a traditional Chinese medicine,has been widely used for nerve protection and nerve function rehabilitation after cerebral stroke.However,the role of FOR in autophagic lysosome function in cerebral ischemiareperfusion damage has not been investigated.This study aimed to explore whether the therapeutic benefits of FOR were influenced by the regulation of autophagy flux.Methods Male Sprague-Dawley rats were separated into sham,model,and MCAO+FOR(30 mg/kg)groups after undergoing middle cerebral artery occlusion(MCAO)and ischemia-reperfusion(I/R).Then,the brain tissues in the ischemic penumbra were obtained to detect the proteins in autophagic/lysosomal pathway with antibodies of Beclin-1,LC3,SQSTM1/P62,Ubiquitin,LAMP-2,Cathepsin B(CTSB)and Cathepsin D(CTSD)by Western blot and immunofluorescence,respectively.Meanwhile,the therapeutic effectiveness was evaluated by measuring infarct volume,neurological impairments,and neuronal necrosis.Results The findings of this study demonstrate that FOR treatment exhibits a dual effect by enhancing the autophagic activities of Beclin-1 and LC3 in neurons,while simultaneously improving the autophagic clearance function,as evidenced by reinforced lysosomal activities of LAMP-2,CTSB,and CTSD,as well as reduced autophagic accumulation of Ubiquitin and P62 in the MCAO+FOR group compared to the MCAO group.Additionally,7 d of FOR treatment dramatically reduced neurological deficits,infarct volume,and neuronal death caused by cerebral ischemia.Conclusion These findings suggest that the neuroprotective mechanism of FOR therapy in accelerating recovery from ischemic stroke may involve the increase of autophagy flux in the penumbra.
