International freedom of the air(traffic rights)is a key resource for airlines to carry out international air transport business.An efficient and reasonable traffic right resource allocation within a country between a...International freedom of the air(traffic rights)is a key resource for airlines to carry out international air transport business.An efficient and reasonable traffic right resource allocation within a country between airlines can affect the quality of a country’s participation in international air transport.In this paper,a multi-objective mixed-integer programming model for traffic rights resource allocation is developed to minimize passenger travel mileages and maximize the number of traffic rights resources allocated to hub airports and competitive carriers.A hybrid heuristic algorithm combining the genetic algorithm and the variable neighborhood search is devised to solve the model.The results show that the optimal allocation scheme aligns with the principle of fairness,indicating that the proposed model can play a certain guiding role in and provide an innovative perspective on traffic rights resource allocation in various countries.展开更多
OBJECTIVE Right ventricular(RV)remodeling is one of the essential pathological features in pulmonary arterial hypertension(PAH).RV hypertrophy or fibrosis are the leading causes of RV remodeling.Magnolol is a compound...OBJECTIVE Right ventricular(RV)remodeling is one of the essential pathological features in pulmonary arterial hypertension(PAH).RV hypertrophy or fibrosis are the leading causes of RV remodeling.Magnolol is a compound isolated from Magnolia officinalis.It possesses multiple pharmacological activities,such as anti-oxidation and anti-inflammation.This study aims to evaluate the effects and underlying mechanisms of magnolol on RV remodeling in hypoxia-induced PAH.METHODS①Male SD rats(220 g)were randomly divided into 5 groups(n=10):the normoxia group,the hypoxia group,the hypoxia plus Magnolol(10 and 20 mg·kg^(-1)·d-1)group,and the vehicle group.Rats in the normoxia group were kept in a normoxia environment for 4 weeks,while rats in the hypoxia group were kept in a hypoxic chamber(10%O2).The rats in the hypoxia plus magnolol groups were administered with magnolol at 10 or 20 mg·kg^(-1)(ip)once a day for 4 weeks.At the end of 4 weeks,the heart function was assessed by Doppler echocardiography,and then the rats were anesthetized with sodium pentobarbital(30 mg·kg^(-1),ip).The RVSP was measured by the right heart catheterization method.The heart tissues were collected and dissected to calculate the index of RV remodeling(RV/LV+IVS,RV/tibial length,or RV/body weight).Part of the RV samples was fixed with 4%paraformaldehyde for morphological analysis,while other samples were frozen at-80℃for molecular studies(measurements of ANP,BNP,α-SMA,and collagenⅠ/ⅢmRNA expression as well as p-JAK2/JAK2 and p-STAT3/STAT3 protein levels).②To evaluate the effect of magnolol on hypoxia-induced myocardial hypertrophy and fibrosis,H9c2 or cardiac fibroblasts were divided into 7 groups:the control group,cells were cultured under normal conditions;the hypoxia group,cells were cultured under hypoxic condition(3%O2);the hypoxia plus magnolol 10 mg·kg^(-1) group,magnolol10μmol·L^(-1) was added to the culture medium before the hypoxia treatment;the hypoxia plus magnolol 30 mg·kg^(-1) group,magnolol 20μmol·L^(-1) was added to the culture medium before the hypoxia treatment;the hypoxia plus TG-101348 group,TG-101348(a specific inhibitor of JAK2)1μmol·L^(-1) was added to the culture medium before the hypoxia treatment;the hypoxia plus JSI-124 group,JSI-124(a specific inhibitor of JAK2)1μmol·L^(-1) was added to the culture medium before the hypoxia treatment;and the hypoxia plus vehicle group,an equal volume of vehicle(DMSO)was added to the culture medium before the hypoxia treatment.At the end of the experiments,the cells were collected for morphological and molecular analysis.RESULTS In vivo,male Sprang-Daley rats were exposed to 10%O2 for 4 weeks to establish an RV remodeling model,which showed hypertrophic and fibrotic features(increases of RV remodeling index,cellular size,hypertrophic and fibrotic marker expression),accompanied by an elevation in phosphorylation levels of JAK2 and STAT3;these changes were attenuated by treating rats with magnolol.In vitro,the cultured H9c2 cells or cardiac fibroblasts were exposed to 3%O2 for 48 h to induce hypertrophy or fibrosis,which showed hypertrophic(increases in cellular size as well as the expression of ANP and BNP)or fibrotic features(increases in the expression of collagenⅠ,collagenⅢandα-SMA).Administration of magnolol and TG-101348 or JSI-124 (JAK2 selective inhibitors) could prevent the process of myocardial hypertrophy and fibrosis, accompanied by the decrease in the phosphorylation level of JAK2 and STAT3. CONCLUSION Magnolol can attenuate RV hypertrophy and fibrosis in hypoxia-induced PAH rats through a mechanism involving inhibition of the JAK2/STAT3 signaling pathway.展开更多
Groundwater is an important water resource in Haihe River basin,North China.The number of aquifers that appear to be declining under conditions of groundwater overdraft is increasing.To effectively manage the water re...Groundwater is an important water resource in Haihe River basin,North China.The number of aquifers that appear to be declining under conditions of groundwater overdraft is increasing.To effectively manage the water resources,there is a strong scientific need to analyze the net use of this important water resource and to quantify the water rights allocation for improved understanding of the future water展开更多
Background and Objective Cardiac pacing is an effective therapy in patients with bradycardia.Conventional right ventricular(RV)pacing is the source of ventricular dyssynchrony,leading to unfavorable clinical outcome.T...Background and Objective Cardiac pacing is an effective therapy in patients with bradycardia.Conventional right ventricular(RV)pacing is the source of ventricular dyssynchrony,leading to unfavorable clinical outcome.This study compared the electrocardiogram(ECG)characteristics during left bundle branch pacing(LBBP)with that during RV septal pacing(RVSP)which has been thought to be better than RV apical pacing.展开更多
Background Arrhythmogenic right ventricular cardiomyopathy(ARVC)is an inherited primary cardiomyopathy characterized by myocardial degeneration with fibro-fatty replacement.Clinical and genetic features of ARVC were w...Background Arrhythmogenic right ventricular cardiomyopathy(ARVC)is an inherited primary cardiomyopathy characterized by myocardial degeneration with fibro-fatty replacement.Clinical and genetic features of ARVC were well identified in Caucasian cohorts,but seldom examined in Chinese cohort.Our aim is to examine the genetic factor,genotype-phenotype correlations,and inheritance patterns of ARVC in a Chinese cohort.展开更多
Numerical methods for Differential-Algebraic systems with discontinuous right-hand sides is discussed. A class of continuous Rosenbrock methods are constructed, and numerical experiments show that the continuous Rosen...Numerical methods for Differential-Algebraic systems with discontinuous right-hand sides is discussed. A class of continuous Rosenbrock methods are constructed, and numerical experiments show that the continuous Rosenbrock methods are effective. Applying the methods, a fast and high-precision numerical algorithm is given to deal with typical discontinuous parts, which occur frequently in differential-algebraic systems(DAS).展开更多
How to protect the disabled children’s rights and interests legally has been a very serious,urgent realistic subject.Today,the problems in the protection of the disabled children’s rights and interests become obviou...How to protect the disabled children’s rights and interests legally has been a very serious,urgent realistic subject.Today,the problems in the protection of the disabled children’s rights and interests become obvious,mainly including that the right to exist is not protected,the right to education is changed,the right to development is not implemented,the right to participate is not respected,and the right to be protected is not safeguarded,etc.As the legal position of the protection of the disabled children’s rights and interests is absent,it is imperative to choose the legal support ways for the protection of the disabled children’s rights and interests.展开更多
This article proves existence results for singular problem ( - 1)n-px(n)(t) = f(t,x(t),…,x(n-1)(t)), for 0 < t < l,x(i)(0) = 0,i = 1,2.…,p - l,x(i)(1) = 0,i = p,p + 1,…, n - 1. Here the positive Carathedory f...This article proves existence results for singular problem ( - 1)n-px(n)(t) = f(t,x(t),…,x(n-1)(t)), for 0 < t < l,x(i)(0) = 0,i = 1,2.…,p - l,x(i)(1) = 0,i = p,p + 1,…, n - 1. Here the positive Carathedory function f may be singular at the zero value of all its phase variables. The interesting point is that the degrees of some variables in the nonlinear term f(t,x0,x1,…,xn-1) are allowable to be greater than 1. Proofs are based on the Leray-Schauder degree theory and Vitali's convergence theorem. The emphasis in this article is that f depends on all higher-order derivatives. Examples are given to illustrate the main results of this article.展开更多
基金supported by the National Natural Science Foundation of Chinathe Civil Aviation Administration of China (U2333206).
文摘International freedom of the air(traffic rights)is a key resource for airlines to carry out international air transport business.An efficient and reasonable traffic right resource allocation within a country between airlines can affect the quality of a country’s participation in international air transport.In this paper,a multi-objective mixed-integer programming model for traffic rights resource allocation is developed to minimize passenger travel mileages and maximize the number of traffic rights resources allocated to hub airports and competitive carriers.A hybrid heuristic algorithm combining the genetic algorithm and the variable neighborhood search is devised to solve the model.The results show that the optimal allocation scheme aligns with the principle of fairness,indicating that the proposed model can play a certain guiding role in and provide an innovative perspective on traffic rights resource allocation in various countries.
文摘OBJECTIVE Right ventricular(RV)remodeling is one of the essential pathological features in pulmonary arterial hypertension(PAH).RV hypertrophy or fibrosis are the leading causes of RV remodeling.Magnolol is a compound isolated from Magnolia officinalis.It possesses multiple pharmacological activities,such as anti-oxidation and anti-inflammation.This study aims to evaluate the effects and underlying mechanisms of magnolol on RV remodeling in hypoxia-induced PAH.METHODS①Male SD rats(220 g)were randomly divided into 5 groups(n=10):the normoxia group,the hypoxia group,the hypoxia plus Magnolol(10 and 20 mg·kg^(-1)·d-1)group,and the vehicle group.Rats in the normoxia group were kept in a normoxia environment for 4 weeks,while rats in the hypoxia group were kept in a hypoxic chamber(10%O2).The rats in the hypoxia plus magnolol groups were administered with magnolol at 10 or 20 mg·kg^(-1)(ip)once a day for 4 weeks.At the end of 4 weeks,the heart function was assessed by Doppler echocardiography,and then the rats were anesthetized with sodium pentobarbital(30 mg·kg^(-1),ip).The RVSP was measured by the right heart catheterization method.The heart tissues were collected and dissected to calculate the index of RV remodeling(RV/LV+IVS,RV/tibial length,or RV/body weight).Part of the RV samples was fixed with 4%paraformaldehyde for morphological analysis,while other samples were frozen at-80℃for molecular studies(measurements of ANP,BNP,α-SMA,and collagenⅠ/ⅢmRNA expression as well as p-JAK2/JAK2 and p-STAT3/STAT3 protein levels).②To evaluate the effect of magnolol on hypoxia-induced myocardial hypertrophy and fibrosis,H9c2 or cardiac fibroblasts were divided into 7 groups:the control group,cells were cultured under normal conditions;the hypoxia group,cells were cultured under hypoxic condition(3%O2);the hypoxia plus magnolol 10 mg·kg^(-1) group,magnolol10μmol·L^(-1) was added to the culture medium before the hypoxia treatment;the hypoxia plus magnolol 30 mg·kg^(-1) group,magnolol 20μmol·L^(-1) was added to the culture medium before the hypoxia treatment;the hypoxia plus TG-101348 group,TG-101348(a specific inhibitor of JAK2)1μmol·L^(-1) was added to the culture medium before the hypoxia treatment;the hypoxia plus JSI-124 group,JSI-124(a specific inhibitor of JAK2)1μmol·L^(-1) was added to the culture medium before the hypoxia treatment;and the hypoxia plus vehicle group,an equal volume of vehicle(DMSO)was added to the culture medium before the hypoxia treatment.At the end of the experiments,the cells were collected for morphological and molecular analysis.RESULTS In vivo,male Sprang-Daley rats were exposed to 10%O2 for 4 weeks to establish an RV remodeling model,which showed hypertrophic and fibrotic features(increases of RV remodeling index,cellular size,hypertrophic and fibrotic marker expression),accompanied by an elevation in phosphorylation levels of JAK2 and STAT3;these changes were attenuated by treating rats with magnolol.In vitro,the cultured H9c2 cells or cardiac fibroblasts were exposed to 3%O2 for 48 h to induce hypertrophy or fibrosis,which showed hypertrophic(increases in cellular size as well as the expression of ANP and BNP)or fibrotic features(increases in the expression of collagenⅠ,collagenⅢandα-SMA).Administration of magnolol and TG-101348 or JSI-124 (JAK2 selective inhibitors) could prevent the process of myocardial hypertrophy and fibrosis, accompanied by the decrease in the phosphorylation level of JAK2 and STAT3. CONCLUSION Magnolol can attenuate RV hypertrophy and fibrosis in hypoxia-induced PAH rats through a mechanism involving inhibition of the JAK2/STAT3 signaling pathway.
文摘Groundwater is an important water resource in Haihe River basin,North China.The number of aquifers that appear to be declining under conditions of groundwater overdraft is increasing.To effectively manage the water resources,there is a strong scientific need to analyze the net use of this important water resource and to quantify the water rights allocation for improved understanding of the future water
文摘Background and Objective Cardiac pacing is an effective therapy in patients with bradycardia.Conventional right ventricular(RV)pacing is the source of ventricular dyssynchrony,leading to unfavorable clinical outcome.This study compared the electrocardiogram(ECG)characteristics during left bundle branch pacing(LBBP)with that during RV septal pacing(RVSP)which has been thought to be better than RV apical pacing.
文摘Background Arrhythmogenic right ventricular cardiomyopathy(ARVC)is an inherited primary cardiomyopathy characterized by myocardial degeneration with fibro-fatty replacement.Clinical and genetic features of ARVC were well identified in Caucasian cohorts,but seldom examined in Chinese cohort.Our aim is to examine the genetic factor,genotype-phenotype correlations,and inheritance patterns of ARVC in a Chinese cohort.
文摘Numerical methods for Differential-Algebraic systems with discontinuous right-hand sides is discussed. A class of continuous Rosenbrock methods are constructed, and numerical experiments show that the continuous Rosenbrock methods are effective. Applying the methods, a fast and high-precision numerical algorithm is given to deal with typical discontinuous parts, which occur frequently in differential-algebraic systems(DAS).
基金The Philosophy and Social Science Research Fund Project for Institutions of Higher Learning in Jiangsu Province:Research on the Right of the Disabled Children to Social Participation-Jiangsu Province Is for Example(No.2014SJB296)
文摘How to protect the disabled children’s rights and interests legally has been a very serious,urgent realistic subject.Today,the problems in the protection of the disabled children’s rights and interests become obvious,mainly including that the right to exist is not protected,the right to education is changed,the right to development is not implemented,the right to participate is not respected,and the right to be protected is not safeguarded,etc.As the legal position of the protection of the disabled children’s rights and interests is absent,it is imperative to choose the legal support ways for the protection of the disabled children’s rights and interests.
基金Supported by National Natural Sciences Foundation of China(10371006)Foundation for PhD Specialities of Educational Department of China(20050007011).
文摘This article proves existence results for singular problem ( - 1)n-px(n)(t) = f(t,x(t),…,x(n-1)(t)), for 0 < t < l,x(i)(0) = 0,i = 1,2.…,p - l,x(i)(1) = 0,i = p,p + 1,…, n - 1. Here the positive Carathedory function f may be singular at the zero value of all its phase variables. The interesting point is that the degrees of some variables in the nonlinear term f(t,x0,x1,…,xn-1) are allowable to be greater than 1. Proofs are based on the Leray-Schauder degree theory and Vitali's convergence theorem. The emphasis in this article is that f depends on all higher-order derivatives. Examples are given to illustrate the main results of this article.
