The response wavelength of the blocked-impurity-band(BIB)structured infrared detector can reach 200µm,which is the most important very long wavelength infrared astronomical detector.The ion implantation method gr...The response wavelength of the blocked-impurity-band(BIB)structured infrared detector can reach 200µm,which is the most important very long wavelength infrared astronomical detector.The ion implantation method greatly simplifies the fabrication process of the device,but it is easy to cause lattice damage,introduce crystalline defects,and lead to the increase of the dark current of detectors.Herein,the boron-doped germanium ion implantation process was studied,and the involved lattice damage mechanism was discussed.Experimental conditions involved using 80 keV energy for boron ion implantation,with doses ranging from 1×10^(13)cm^(-2)to 3×10^(15)cm^(-2).After implantation,thermal annealing at 450℃was implemented to optimize dopant activation and mitigate the effects of ion implantation.Various sophisticated characterization techniques,including X-ray dif⁃fraction(XRD),Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),and secondary ion mass spec⁃trometry(SIMS)were used to clarify lattice damage.At lower doses,no notable structural alterations were ob⁃served.However,as the dosage increased,specific micro distortions became apparent,which could be attributed to point defects and residual strain.The created lattice damage was recovered by thermal treatment,however,an irreversible strain induced by implantation still existed at heavily dosed samples.展开更多
Nanocomposite multilayer TiBN coatings were prepared on Si(100) and 9Cr18Mo substrates using TiBN composite cathode plasma immersion ion implantation and deposition technique(PIIID). Synthesis of TiBN composite cathod...Nanocomposite multilayer TiBN coatings were prepared on Si(100) and 9Cr18Mo substrates using TiBN composite cathode plasma immersion ion implantation and deposition technique(PIIID). Synthesis of TiBN composite cathodes was conducted by powder metallurgy technology and the content of hexagonal boron nitride(h-BN) was changed from 8% to 40%(mass fraction). The as-deposited coatings were characterized by energy dispersive spectrometer(EDS), grazing incidence X-ray diffraction(GIXRD), Fourier Transform Infrared Spectroscopy(FTIR) and high resolution transmission electron microcopy(HRTEM). EDS results show that the B content of the coatings was varied from 3.71% to 13.84%(molar fraction) when the composition of the h-BN in the composited cathodes was changed from 8 % to 40%(mass fraction). GIXRD results reveal that the TiBN coatings with a B content of 8% has the main diffraction peak of TiN(200),(220) and(311), and these peaks disappear when the B content is increased. FTIR analysis of the multilayer coatings showed the presence of h-BN in all coatings. TEM images reveal that all coatings have the characteristics of self-forming nanocomposite multilayers, where the nanocomposites are composed of face-centered cubic Ti N or h-BN nanocrystalline embedded in amorphous matrix. The tribological tests reveal that the Ti BN coatings exhibit a marked decrease of coefficient at room temperature(~0.25). The improved properties were found to be derived from the comprehensiveness of the self-forming multilayers structure and the h-BN solid lubrication effects in the coatings.展开更多
To investigate the expression of Prominin-1(Prom-1)in mouse uterus during peri-implantation.In situ hybridization and immunohistochemical staining were used to detect the mRNA and protein expression level of Prom-1 in...To investigate the expression of Prominin-1(Prom-1)in mouse uterus during peri-implantation.In situ hybridization and immunohistochemical staining were used to detect the mRNA and protein expression level of Prom-1 in mice uterus in early pregnancy,pseudopregnancy,estrous cycle,treated with hormone,delayed implantation and activation models.The results showed that Prom-1 was gradually weakened in uterine luminal epithelium(LE)and glandular epithelium(GE)during days 1-4 of pregnancy.During days 5-8,Prom-1 was strongly expressed in GE,and signal of Prom-1 protein was detected in matrix and decidua around the embryo.Similar to pregnancy,Prom-1 was strongly expressed in LE and GE on the 1st day and weakly expressed on the 4th day of pseudopregnancy.In addition,Prom-1 was highly expressed in LE and GE on estrus.Expression of Prom-1 was observed in the LE and the GE of delayed-implantation uterus.In activated-implantation animal model,Prom-1 was strongly expressed in the GE.In the hormone-treated model,Prom-1 expression levels were higher in the uterus of the 17β-estradiol-treated group than those in the control group.These results indicated that Prom-1 might promote the proliferation of mouse endometrial epithelium and participate in the establishment of uterine receptivity.Meanwhile,the expression of Prom-1 was up-regulated by the 17β-estradiol,indicating that Prom-1 might involve in the process of decidua development regulated by uterine glands,and Prom-1 might play an important role in mice early pregnancy.展开更多
Lipopolysaccharide-binding protein(LBP)functions as an acute phase protein and plays a role in the innate immune response to bacterial challenge.To investigate the uterine expression of LBP during peri-implantation in...Lipopolysaccharide-binding protein(LBP)functions as an acute phase protein and plays a role in the innate immune response to bacterial challenge.To investigate the uterine expression of LBP during peri-implantation in mice,in situ hybridization and immunohistochemical staining were used to detect the mRNA and protein expression of LBP in mouse uteri in the early pregnancy,pseudopregnancy,artificial decidualization and hormone-treated mice.The results showed that LBP was expressed in uterine luminal epithelium(LE)and glandular epithelium(GE)during days 1-4 of pregnancy.During days 5-8,LBP was weakly expressed in the decidual cells around the embryo on the 5th day of pregnancy(implantation occurred),then gradually increased,LBP was strongly expressed in the decidual zone on the 8th day of pregnancy.The expression of LBP in pseudopregnancy was similar with pregnancy on days 1-4.In artificial decidualization mice,LBP was observed in uterine LE and GE in the control horn,whereas LBP expression was significantly higher in decidua of mouse uteri under artificial decidualization.In hormone-treated mice,the expression of LBP wasup-regulated by 17β-estradiol(E2)and progesterone(P4).In addition,the cultured mouse endometrial stromal cells(mESCs)were induced for in vitro decidualization with 10 nmol·L-1 E2 and 1μmol·L-1 P4.Real-time PCR results showed that LBP mRNA expression was highly induced in mESCs after decidual stimulus.In vivo and in vitro experiments showed that LBP was expressed in the decidual cells,indicating that LBP involved in decidualization of mouse uteri.展开更多
The surface layer of beryllium, specimen, has been strengthened by ion implantation. Its microhardness was measured. The hardness of surface layer has been calculated from the microhardness. The experimental data of t...The surface layer of beryllium, specimen, has been strengthened by ion implantation. Its microhardness was measured. The hardness of surface layer has been calculated from the microhardness. The experimental data of the wear rate indirectly Confirmed the reasonableness of the result of calculation. It is shown that the hardness of the surface layer strengthened, by ion implantation is nine times higher than that of beryllium itself. The relation between hardness and implantation dose was analysed and the best dose was obtained.展开更多
In this study,Mg-based composites,by the addition of ZnO,Ca_(2)ZnSi_(2)O_(7),Ca_(2)MgSi_(2)O_(7),and CaSiO_(3)as bioactive agents,were fabricated using friction stir processing.The microstructure and in vitro assessme...In this study,Mg-based composites,by the addition of ZnO,Ca_(2)ZnSi_(2)O_(7),Ca_(2)MgSi_(2)O_(7),and CaSiO_(3)as bioactive agents,were fabricated using friction stir processing.The microstructure and in vitro assessment of bioactivity,biodegradation rate,and corrosion behavior of the resultant composites were investigated in simulated body fluid(SBF).The results showed that during the immersion of composites in SBF for 28 d,due to the release of Ca^(2+)and PO_(4)^(3-)ions,hydroxyapatite(HA)crystals with cauliflower shaped morphology were deposited on the surface of composites,confirming good bioactivity of composites.In addition,due to the uniform distribution of bioceramic powders throughout Mg matrix,grain refinement of the Mg matrix,and uniform redistribution of secondary phase particles,the polarization resistance increased,and the biodegradation rate of composites significantly reduced compared to monolithic Mg matrix.The polarization corrosion resistance of Mg-ZnO increased from 0.216 to 2.499 kΩ/cm^(2)compared to monolithic Mg alloy.Additionally,Mg-ZnO composite with the weight loss of 0.0217 g after 28 d immersion showed lower weight loss compared to other samples with increasing immersion time.Moreover,Mg-ZnO composite with the biodegradation rate of 37.71 mm/a exhibited lower biodegradation rate compared to other samples with increasing immersion time.展开更多
目的评估人工耳蜗对单侧聋及不对称性听力损失(asymmetric hearing loss,AHL)患者听觉言语质量改善情况。方法选取首都医科大学附属北京同仁医院于2020年8月至2021年9月纳入的16例母语为汉语普通话的成人单侧聋及AHL人工耳蜗患者。其中...目的评估人工耳蜗对单侧聋及不对称性听力损失(asymmetric hearing loss,AHL)患者听觉言语质量改善情况。方法选取首都医科大学附属北京同仁医院于2020年8月至2021年9月纳入的16例母语为汉语普通话的成人单侧聋及AHL人工耳蜗患者。其中,男性8例,女性8例,年龄24~56岁,平均年龄36.9岁。单侧聋患者11例、AHL患者5例。采用言语、空间和音质听觉量表(speech,spatial and qualities of hearing scale,SSQ)评估上述患者在术前和开机两年言语感知、空间听觉和声音聆听质量的改善情况,并对各分量表得分变化进行比较。同时进一步比较单侧聋组和AHL组人工耳蜗术后听觉言语感知获益的差异。结果单侧聋和AHL患者人工耳蜗开机两年后SSQ总分及3个维度得分均较术前提高,且有统计学差异(P<0.05)。单侧聋及AHL患者在涉及言语理解的4个分量表助听前后得分均有显著性提高;在空间听觉方面,对定位、距离和移动的感知也有显著性改善;在声音聆听质量方面,听配能有显著性差异(Z=-2.70,P=0.004),但助听后声音聆听质量和自然度、识别声音和分离声音分量表得分有提高但无显著性差异。单侧聋组和AHL组患者人工耳蜗术后各维度得分的变化情况无显著性差异。结论人工耳蜗植入可帮助多数单侧聋和AHL患者提高言语空间听觉质量,减少听觉疲劳。展开更多
基金Supported by National Key R&D Program of China(2023YFA1608701)National Natural Science Foundation of China(62274168,11933006,U2141240)Hangzhou Leading Innovation and Entrepreneurship Team(TD2020002)。
文摘The response wavelength of the blocked-impurity-band(BIB)structured infrared detector can reach 200µm,which is the most important very long wavelength infrared astronomical detector.The ion implantation method greatly simplifies the fabrication process of the device,but it is easy to cause lattice damage,introduce crystalline defects,and lead to the increase of the dark current of detectors.Herein,the boron-doped germanium ion implantation process was studied,and the involved lattice damage mechanism was discussed.Experimental conditions involved using 80 keV energy for boron ion implantation,with doses ranging from 1×10^(13)cm^(-2)to 3×10^(15)cm^(-2).After implantation,thermal annealing at 450℃was implemented to optimize dopant activation and mitigate the effects of ion implantation.Various sophisticated characterization techniques,including X-ray dif⁃fraction(XRD),Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),and secondary ion mass spec⁃trometry(SIMS)were used to clarify lattice damage.At lower doses,no notable structural alterations were ob⁃served.However,as the dosage increased,specific micro distortions became apparent,which could be attributed to point defects and residual strain.The created lattice damage was recovered by thermal treatment,however,an irreversible strain induced by implantation still existed at heavily dosed samples.
基金Projects(21573054,21327002,51401201)supported by the National Natural Science Foundation of ChinaProject(U1537214)supported by the Joint Funds Key Project of the National Natural Science Foundation of ChinaProject(51535003)supported by the State Key Program of National Natural Science of China
文摘Nanocomposite multilayer TiBN coatings were prepared on Si(100) and 9Cr18Mo substrates using TiBN composite cathode plasma immersion ion implantation and deposition technique(PIIID). Synthesis of TiBN composite cathodes was conducted by powder metallurgy technology and the content of hexagonal boron nitride(h-BN) was changed from 8% to 40%(mass fraction). The as-deposited coatings were characterized by energy dispersive spectrometer(EDS), grazing incidence X-ray diffraction(GIXRD), Fourier Transform Infrared Spectroscopy(FTIR) and high resolution transmission electron microcopy(HRTEM). EDS results show that the B content of the coatings was varied from 3.71% to 13.84%(molar fraction) when the composition of the h-BN in the composited cathodes was changed from 8 % to 40%(mass fraction). GIXRD results reveal that the TiBN coatings with a B content of 8% has the main diffraction peak of TiN(200),(220) and(311), and these peaks disappear when the B content is increased. FTIR analysis of the multilayer coatings showed the presence of h-BN in all coatings. TEM images reveal that all coatings have the characteristics of self-forming nanocomposite multilayers, where the nanocomposites are composed of face-centered cubic Ti N or h-BN nanocrystalline embedded in amorphous matrix. The tribological tests reveal that the Ti BN coatings exhibit a marked decrease of coefficient at room temperature(~0.25). The improved properties were found to be derived from the comprehensiveness of the self-forming multilayers structure and the h-BN solid lubrication effects in the coatings.
基金Supported by the National Natural Science Foundation of China(31472097)
文摘To investigate the expression of Prominin-1(Prom-1)in mouse uterus during peri-implantation.In situ hybridization and immunohistochemical staining were used to detect the mRNA and protein expression level of Prom-1 in mice uterus in early pregnancy,pseudopregnancy,estrous cycle,treated with hormone,delayed implantation and activation models.The results showed that Prom-1 was gradually weakened in uterine luminal epithelium(LE)and glandular epithelium(GE)during days 1-4 of pregnancy.During days 5-8,Prom-1 was strongly expressed in GE,and signal of Prom-1 protein was detected in matrix and decidua around the embryo.Similar to pregnancy,Prom-1 was strongly expressed in LE and GE on the 1st day and weakly expressed on the 4th day of pseudopregnancy.In addition,Prom-1 was highly expressed in LE and GE on estrus.Expression of Prom-1 was observed in the LE and the GE of delayed-implantation uterus.In activated-implantation animal model,Prom-1 was strongly expressed in the GE.In the hormone-treated model,Prom-1 expression levels were higher in the uterus of the 17β-estradiol-treated group than those in the control group.These results indicated that Prom-1 might promote the proliferation of mouse endometrial epithelium and participate in the establishment of uterine receptivity.Meanwhile,the expression of Prom-1 was up-regulated by the 17β-estradiol,indicating that Prom-1 might involve in the process of decidua development regulated by uterine glands,and Prom-1 might play an important role in mice early pregnancy.
基金Supported by the National Natural Science Foundation of China(31472097)。
文摘Lipopolysaccharide-binding protein(LBP)functions as an acute phase protein and plays a role in the innate immune response to bacterial challenge.To investigate the uterine expression of LBP during peri-implantation in mice,in situ hybridization and immunohistochemical staining were used to detect the mRNA and protein expression of LBP in mouse uteri in the early pregnancy,pseudopregnancy,artificial decidualization and hormone-treated mice.The results showed that LBP was expressed in uterine luminal epithelium(LE)and glandular epithelium(GE)during days 1-4 of pregnancy.During days 5-8,LBP was weakly expressed in the decidual cells around the embryo on the 5th day of pregnancy(implantation occurred),then gradually increased,LBP was strongly expressed in the decidual zone on the 8th day of pregnancy.The expression of LBP in pseudopregnancy was similar with pregnancy on days 1-4.In artificial decidualization mice,LBP was observed in uterine LE and GE in the control horn,whereas LBP expression was significantly higher in decidua of mouse uteri under artificial decidualization.In hormone-treated mice,the expression of LBP wasup-regulated by 17β-estradiol(E2)and progesterone(P4).In addition,the cultured mouse endometrial stromal cells(mESCs)were induced for in vitro decidualization with 10 nmol·L-1 E2 and 1μmol·L-1 P4.Real-time PCR results showed that LBP mRNA expression was highly induced in mESCs after decidual stimulus.In vivo and in vitro experiments showed that LBP was expressed in the decidual cells,indicating that LBP involved in decidualization of mouse uteri.
基金This project was suportod by Reijing Zhongguancun Associated Center of Analysis and Measurement
文摘The surface layer of beryllium, specimen, has been strengthened by ion implantation. Its microhardness was measured. The hardness of surface layer has been calculated from the microhardness. The experimental data of the wear rate indirectly Confirmed the reasonableness of the result of calculation. It is shown that the hardness of the surface layer strengthened, by ion implantation is nine times higher than that of beryllium itself. The relation between hardness and implantation dose was analysed and the best dose was obtained.
文摘In this study,Mg-based composites,by the addition of ZnO,Ca_(2)ZnSi_(2)O_(7),Ca_(2)MgSi_(2)O_(7),and CaSiO_(3)as bioactive agents,were fabricated using friction stir processing.The microstructure and in vitro assessment of bioactivity,biodegradation rate,and corrosion behavior of the resultant composites were investigated in simulated body fluid(SBF).The results showed that during the immersion of composites in SBF for 28 d,due to the release of Ca^(2+)and PO_(4)^(3-)ions,hydroxyapatite(HA)crystals with cauliflower shaped morphology were deposited on the surface of composites,confirming good bioactivity of composites.In addition,due to the uniform distribution of bioceramic powders throughout Mg matrix,grain refinement of the Mg matrix,and uniform redistribution of secondary phase particles,the polarization resistance increased,and the biodegradation rate of composites significantly reduced compared to monolithic Mg matrix.The polarization corrosion resistance of Mg-ZnO increased from 0.216 to 2.499 kΩ/cm^(2)compared to monolithic Mg alloy.Additionally,Mg-ZnO composite with the weight loss of 0.0217 g after 28 d immersion showed lower weight loss compared to other samples with increasing immersion time.Moreover,Mg-ZnO composite with the biodegradation rate of 37.71 mm/a exhibited lower biodegradation rate compared to other samples with increasing immersion time.
文摘目的评估人工耳蜗对单侧聋及不对称性听力损失(asymmetric hearing loss,AHL)患者听觉言语质量改善情况。方法选取首都医科大学附属北京同仁医院于2020年8月至2021年9月纳入的16例母语为汉语普通话的成人单侧聋及AHL人工耳蜗患者。其中,男性8例,女性8例,年龄24~56岁,平均年龄36.9岁。单侧聋患者11例、AHL患者5例。采用言语、空间和音质听觉量表(speech,spatial and qualities of hearing scale,SSQ)评估上述患者在术前和开机两年言语感知、空间听觉和声音聆听质量的改善情况,并对各分量表得分变化进行比较。同时进一步比较单侧聋组和AHL组人工耳蜗术后听觉言语感知获益的差异。结果单侧聋和AHL患者人工耳蜗开机两年后SSQ总分及3个维度得分均较术前提高,且有统计学差异(P<0.05)。单侧聋及AHL患者在涉及言语理解的4个分量表助听前后得分均有显著性提高;在空间听觉方面,对定位、距离和移动的感知也有显著性改善;在声音聆听质量方面,听配能有显著性差异(Z=-2.70,P=0.004),但助听后声音聆听质量和自然度、识别声音和分离声音分量表得分有提高但无显著性差异。单侧聋组和AHL组患者人工耳蜗术后各维度得分的变化情况无显著性差异。结论人工耳蜗植入可帮助多数单侧聋和AHL患者提高言语空间听觉质量,减少听觉疲劳。
