免疫性皮肤病指一类免疫系统介导的自身免疫性或炎症性皮肤病,包括红斑狼疮、银屑病、特应性皮炎和白癜风等。免疫性皮肤病发病机制仍不明确,疾病进程复杂,临床表现多样,治疗困难,给免疫性皮肤病的诊断和治疗带来了巨大挑战。近年来,我...免疫性皮肤病指一类免疫系统介导的自身免疫性或炎症性皮肤病,包括红斑狼疮、银屑病、特应性皮炎和白癜风等。免疫性皮肤病发病机制仍不明确,疾病进程复杂,临床表现多样,治疗困难,给免疫性皮肤病的诊断和治疗带来了巨大挑战。近年来,我国皮肤病学研究者在免疫性皮肤病方面取得了许多创新性研究成果。近10年中国学者在免疫性皮肤病领域发表SCI论文11919篇,其中10余篇发表在顶级期刊,包括发表在科学(Science)1篇、自然(Nature)1篇、细胞(Cell)2篇、新英格兰医学杂志(New England Journal of Medicine)3篇、柳叶刀(The Lancet)2篇、自然医学(Nature Medicine)1篇及免疫(Immunity)4篇等。本文主要就我国在免疫性皮肤病发病机制、诊断及治疗方式等方面的研究进展进行总结。展开更多
Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of...Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of Science for literature related to m^(6)A and dermatological conditions.Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m^(6)A-related research.Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases,particularly melanoma,psoriasis,and skin development.Transcriptomic data from the Gene Expression Omnibus(GEO)were analyzed,revealing differential expression of m^(6)A-related genes in 4 types of skin tumors(including squamous cell carcinoma and basal cell carcinoma)as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis,and potential mechanisms of action were also explored.Findings suggest that m^(6)A modifications exhibit heterogeneity between neoplastic and nonneoplastic skin diseases.However,the regulatory mechanisms of m^(6)A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.展开更多
文摘免疫性皮肤病指一类免疫系统介导的自身免疫性或炎症性皮肤病,包括红斑狼疮、银屑病、特应性皮炎和白癜风等。免疫性皮肤病发病机制仍不明确,疾病进程复杂,临床表现多样,治疗困难,给免疫性皮肤病的诊断和治疗带来了巨大挑战。近年来,我国皮肤病学研究者在免疫性皮肤病方面取得了许多创新性研究成果。近10年中国学者在免疫性皮肤病领域发表SCI论文11919篇,其中10余篇发表在顶级期刊,包括发表在科学(Science)1篇、自然(Nature)1篇、细胞(Cell)2篇、新英格兰医学杂志(New England Journal of Medicine)3篇、柳叶刀(The Lancet)2篇、自然医学(Nature Medicine)1篇及免疫(Immunity)4篇等。本文主要就我国在免疫性皮肤病发病机制、诊断及治疗方式等方面的研究进展进行总结。
基金supported by the National Natural Science Foundation,China(82103704).
文摘Currently,research on N^(6)-methyladenine(m^(6)A)is extensive in the field of oncology,while studies involving m^(6)A and skin diseases remain relatively limited.Based on existing reports,we searched PubMed and Web of Science for literature related to m^(6)A and dermatological conditions.Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m^(6)A-related research.Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases,particularly melanoma,psoriasis,and skin development.Transcriptomic data from the Gene Expression Omnibus(GEO)were analyzed,revealing differential expression of m^(6)A-related genes in 4 types of skin tumors(including squamous cell carcinoma and basal cell carcinoma)as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis,and potential mechanisms of action were also explored.Findings suggest that m^(6)A modifications exhibit heterogeneity between neoplastic and nonneoplastic skin diseases.However,the regulatory mechanisms of m^(6)A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.
