Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,n...Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.展开更多
Energy saving is the most important issue in research and development for wireless sensor networks. A power control mechanism can reduce the power consumption of the whole network. Because the character of wireless se...Energy saving is the most important issue in research and development for wireless sensor networks. A power control mechanism can reduce the power consumption of the whole network. Because the character of wireless sensor networks is restrictive energy, this paper proposes a distributed power control algorithm based on game theory for wireless sensor networks which objects of which are reducing power consumption and decreasing overhead and increasing network lifetime. The game theory and OPNET simulation shows that the power control algorithm converges to a Nash Equilibrium when decisions are updated according to a better response dynamic.展开更多
In operation,risk arising from power transformer faults is of much uncertainty and complicacy.To timely and objectively control the risks,a transformer risk assessment method based on fuzzy analytic hierarchy process(...In operation,risk arising from power transformer faults is of much uncertainty and complicacy.To timely and objectively control the risks,a transformer risk assessment method based on fuzzy analytic hierarchy process(FAHP) and artificial neural network(ANN) from the perspective of accuracy and quickness is proposed.An analytic hierarchy process model for the transformer risk assessment is built by analysis of the risk factors affecting the transformer risk level and the weight relation of each risk factor in transformer risk calculation is analyzed by application of fuzzy consistency judgment matrix;with utilization of adaptive ability and nonlinear mapping ability of the ANN,the risk factors with large weights are used as input of neutral network,and thus intelligent quantitative assessment of transformer risk is realized.The simulation result shows that the proposed method increases the speed and accuracy of the risk assessment and can provide feasible decision basis for the transformer risk management and maintenance decisions.展开更多
Power efficiency and link reliability are of great impor- tance in hierarchical wireless sensor networks （HWSNs）, espe- cially at the key level, which consists of sensor nodes located only one hop away from the sink...Power efficiency and link reliability are of great impor- tance in hierarchical wireless sensor networks （HWSNs）, espe- cially at the key level, which consists of sensor nodes located only one hop away from the sink node called OHS. The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability. This problem is modeled as a non-cooperative game in which the active OHSs are con- sidered as players. By applying a double-pricing scheme in the definition of OHSs＇ utility function, a Nash Equilibrium solution with network properties is derived. Besides, a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium. Finally, the simulation results demonstrate the effec- tiveness of the proposed algorithm.展开更多
In order to accurately forecast the load of power system and enhance the stability of the power network, a novel unascertained mathematics based recurrent neural network (UMRNN) for power intelligence center (PIC) was...In order to accurately forecast the load of power system and enhance the stability of the power network, a novel unascertained mathematics based recurrent neural network (UMRNN) for power intelligence center (PIC) was created through three steps. First, by combining with the general project uncertain element transmission theory (GPUET), the basic definitions of stochastic, fuzzy, and grey uncertain elements were given based on the principal types of uncertain information. Second, a power dynamic alliance including four sectors: generation sector, transmission sector, distribution sector and customers was established. The key factors were amended according to the four transmission topologies of uncertain elements, thus the new factors entered the power intelligence center as the input elements. Finally, in the intelligence handing background of PIC, by performing uncertain and recursive process to the input values of network, and combining unascertained mathematics, the novel load forecasting model was built. Three different approaches were put forward to forecast an eastern regional power grid load in China. The root mean square error (ERMS) demonstrates that the forecasting accuracy of the proposed model UMRNN is 3% higher than that of BP neural network (BPNN), and 5% higher than that of autoregressive integrated moving average (ARIMA). Besides, an example also shows that the average relative error of the first quarter of 2008 forecasted by UMRNN is only 2.59%, which has high precision.展开更多
Considering the factors affecting the increasing rate of power consumption, the BP neural network structure and the neural network forecasting model of the increasing rate of power consumption were established. Immune...Considering the factors affecting the increasing rate of power consumption, the BP neural network structure and the neural network forecasting model of the increasing rate of power consumption were established. Immune genetic algorithm was applied to optimizing the weight from input layer to hidden layer, from hidden layer to output layer, and the threshold value of neuron nodes in hidden and output layers. Finally, training the related data of the increasing rate of power consumption from 1980 to 2000 in China, a nonlinear network model between the increasing rate of power consumption and influencing factors was obtained. The model was adopted to forecasting the increasing rate of power consumption from 2001 to 2005, and the average absolute error ratio of forecasting results is 13.521 8%. Compared with the ordinary neural network optimized by genetic algorithm, the results show that this method has better forecasting accuracy and stability for forecasting the increasing rate of power consumption.展开更多
Electric power is widely used as the main energy source of ship integrated power system(SIPS), which contains power network and electric power network. SIPS network reconfiguration is a non-linear large-scale problem....Electric power is widely used as the main energy source of ship integrated power system(SIPS), which contains power network and electric power network. SIPS network reconfiguration is a non-linear large-scale problem. The reconfiguration solution influences the safety and stable operation of the power system. According to the operational characteristics of SIPS, a simplified model of power network and a mathematical model for network reconfiguration are established. Based on these models, a multi-agent and ant colony optimization(MAACO) is proposed to solve the problem of network reconfiguration. The simulations are carried out to demonstrate that the optimization method can reconstruct the integrated power system network accurately and efficiently.展开更多
A distributed local adaptive transmit power assignment (LA-TPA) strategy was proposed to construct a topology with better performance according to the environment and application scenario and prolong the network lifet...A distributed local adaptive transmit power assignment (LA-TPA) strategy was proposed to construct a topology with better performance according to the environment and application scenario and prolong the network lifetime.It takes the path loss exponent and the energy control coefficient into consideration with the aim to accentuate the minimum covering district of each node more accurately and precisely according to various network application scenarios.Besides,a self-healing scheme that enhances the robustness of the network was provided.It makes the topology tolerate more dead nodes than existing algorithms.Simulation was done under OMNeT++ platform and the results show that the LA-TPA strategy is more effective in constructing a well-performance network topology based on various application scenarios and can prolong the network lifetime significantly.展开更多
Subsurface cavities are very susceptible subsurface locations for down-lifting of a dam construction.In order to detect the low-density zones of a power plant a micro-gravity survey was conducted in a site considered ...Subsurface cavities are very susceptible subsurface locations for down-lifting of a dam construction.In order to detect the low-density zones of a power plant a micro-gravity survey was conducted in a site considered for construction of a power plant site in Iran.First we gain the residual anomalies through bouger anomalies and then we design an Artificial Neural Network(ANN)which is trained by a set of training data.The ANN was tested for both synthetic and real data.For real data some suitable features are derivate from residual anomalies and applied to展开更多
The data gathering manner of wireless sensor networks, in which data is forwarded towards the sink node, would cause the nodes near the sink node to transmit more data than those far from it. Most data gathering mecha...The data gathering manner of wireless sensor networks, in which data is forwarded towards the sink node, would cause the nodes near the sink node to transmit more data than those far from it. Most data gathering mechanisms nowdo not do well in balancing the energy consumption among nodes with different distances to the sink, thus they can hardly avoid the problem that nodes near the sink consume energy more quickly, which may cause the network rupture from the sink node. This paper presents a data gathering mechanism called PODA, which grades the output power of nodes according to their distances from the sink node. PODA balances energy consumption by setting the nodes near the sink with lower output power and the nodes far from the sink with higher output power. Simulation results show that the PODA mechanism can achieve even energy consumption in the entire network, improve energy efficiency and prolong the network lifetime.展开更多
In view of the serious reactive power loss in the rural network, improved ant colony optimization algorithm （ACOA） was used to optimize the reactive power compensation for the rural distribution system. In this stud...In view of the serious reactive power loss in the rural network, improved ant colony optimization algorithm （ACOA） was used to optimize the reactive power compensation for the rural distribution system. In this study, the traditional ACOA was improved in two aspects： one was the local search strategy, and the other was pheromone mutation and re-initialization strategies. The reactive power optimization for a county＇s distribution network showed that the improved ACOA was practicable.展开更多
Rural power network planning is a complicated nonlinear optimized combination problem which based on load forecasting results, and its actual load is affected by many uncertain factors, which influenced optimization r...Rural power network planning is a complicated nonlinear optimized combination problem which based on load forecasting results, and its actual load is affected by many uncertain factors, which influenced optimization results of rural power network planning. To solve the problems, the interval algorithm was used to modify the initial search method of uncertainty load mathematics model in rural network planning. Meanwhile, the genetic/tabu search combination algorithm was adopted to optimize the initialized network. The sample analysis results showed that compared with the certainty planning, the improved method was suitable for urban medium-voltage distribution network planning with consideration of uncertainty load and the planning results conformed to the reality.展开更多
文摘Objective Repetitive transcranial magnetic stimulation(rTMS)has demonstrated efficacy in enhancing neurocognitive performance in Alzheimer’s disease(AD),but the neurobiological mechanisms linking synaptic pathology,neural oscillatory dynamics,and brain network reorganization remain unclear.This investigation seeks to systematically evaluate the therapeutic potential of rTMS as a non-invasive neuromodulatory intervention through a multimodal framework integrating clinical assessments,molecular profiling,and neurophysiological monitoring.Methods In this prospective double-blind trial,12 AD patients underwent a 14-day protocol of 20 Hz rTMS,with comprehensive multimodal assessments performed pre-and postintervention.Cognitive functioning was quantified using the mini-mental state examination(MMSE)and Montreal cognitive assessment(MOCA),while daily living capacities and neuropsychiatric profiles were respectively evaluated through the activities of daily living(ADL)scale and combined neuropsychiatric inventory(NPI)-Hamilton depression rating scale(HAMD).Peripheral blood biomarkers,specifically Aβ1-40 and phosphorylated tau(p-tau181),were analyzed to investigate the effects of rTMS on molecular metabolism.Spectral power analysis was employed to investigate rTMS-induced modulations of neural rhythms in AD patients,while brain network analyses incorporating topological properties were conducted to examine stimulus-driven network reorganization.Furthermore,systematic assessment of correlations between cognitive scale scores,blood biomarkers,and network characteristics was performed to elucidate cross-modal therapeutic associations.Results Clinically,MMSE and MOCA scores improved significantly(P<0.05).Biomarker showed that Aβ1-40 level increased(P<0.05),contrasting with p-tau181 reduction.Moreover,the levels of Aβ1-40 were positively correlated with MMSE and MOCA scores.Post-intervention analyses revealed significant modulations in oscillatory power,characterized by pronounced reductions in delta(P<0.05)and theta bands(P<0.05),while concurrent enhancements were observed in alpha,beta,and gamma band activities(all P<0.05).Network analysis revealed frequency-specific reorganization:clustering coefficients were significantly decreased in delta,theta,and alpha bands(P<0.05),while global efficiency improvement was exclusively detected in the delta band(P<0.05).The alpha band demonstrated concurrent increases in average nodal degree(P<0.05)and characteristic path length reduction(P<0.05).Further research findings indicate that the changes in the clinical scale HAMD scores before and after rTMS stimulation are negatively correlated with the changes in the blood biomarkers Aβ1-40 and p-tau181.Additionally,the changes in the clinical scales MMSE and MoCA scores were negatively correlated with the changes in the node degree of the alpha frequency band and negatively correlated with the clustering coefficient of the delta frequency band.However,the changes in MMSE scores are positively correlated with the changes in global efficiency of both the delta and alpha frequency bands.Conclusion 20 Hz rTMS targeting dorsolateral prefrontal cortex(DLPFC)significantly improves cognitive function and enhances the metabolic clearance ofβ-amyloid and tau proteins in AD patients.This neurotherapeutic effect is mechanistically associated with rTMS-mediated frequency-selective neuromodulation,which enhances the connectivity of oscillatory networks through improved neuronal synchronization and optimized topological organization of functional brain networks.These findings not only support the efficacy of rTMS as an adjunctive therapy for AD but also underscore the importance of employing multiple assessment methods—including clinical scales,blood biomarkers,and EEG——in understanding and monitoring the progression of AD.This research provides a significant theoretical foundation and empirical evidence for further exploration of rTMS applications in AD treatment.
文摘Energy saving is the most important issue in research and development for wireless sensor networks. A power control mechanism can reduce the power consumption of the whole network. Because the character of wireless sensor networks is restrictive energy, this paper proposes a distributed power control algorithm based on game theory for wireless sensor networks which objects of which are reducing power consumption and decreasing overhead and increasing network lifetime. The game theory and OPNET simulation shows that the power control algorithm converges to a Nash Equilibrium when decisions are updated according to a better response dynamic.
基金Project(50977003) supported by the National Natural Science Foundation of China
文摘In operation,risk arising from power transformer faults is of much uncertainty and complicacy.To timely and objectively control the risks,a transformer risk assessment method based on fuzzy analytic hierarchy process(FAHP) and artificial neural network(ANN) from the perspective of accuracy and quickness is proposed.An analytic hierarchy process model for the transformer risk assessment is built by analysis of the risk factors affecting the transformer risk level and the weight relation of each risk factor in transformer risk calculation is analyzed by application of fuzzy consistency judgment matrix;with utilization of adaptive ability and nonlinear mapping ability of the ANN,the risk factors with large weights are used as input of neutral network,and thus intelligent quantitative assessment of transformer risk is realized.The simulation result shows that the proposed method increases the speed and accuracy of the risk assessment and can provide feasible decision basis for the transformer risk management and maintenance decisions.
基金supported by the National Natural Science Foundation of China (7070102571071105)+2 种基金the Program for New Century Excellent Talents in Universities of China (NCET-08-0396)the National Science Fund for Distinguished Young Scholars of China (70925005)the Program for Changjiang Scholars and Innovative Research Team in University (IRT/028)
文摘Power efficiency and link reliability are of great impor- tance in hierarchical wireless sensor networks （HWSNs）, espe- cially at the key level, which consists of sensor nodes located only one hop away from the sink node called OHS. The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability. This problem is modeled as a non-cooperative game in which the active OHSs are con- sidered as players. By applying a double-pricing scheme in the definition of OHSs＇ utility function, a Nash Equilibrium solution with network properties is derived. Besides, a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium. Finally, the simulation results demonstrate the effec- tiveness of the proposed algorithm.
基金Projects(70572090, 70373017) supported by the National Natural Science Foundation of China
文摘In order to accurately forecast the load of power system and enhance the stability of the power network, a novel unascertained mathematics based recurrent neural network (UMRNN) for power intelligence center (PIC) was created through three steps. First, by combining with the general project uncertain element transmission theory (GPUET), the basic definitions of stochastic, fuzzy, and grey uncertain elements were given based on the principal types of uncertain information. Second, a power dynamic alliance including four sectors: generation sector, transmission sector, distribution sector and customers was established. The key factors were amended according to the four transmission topologies of uncertain elements, thus the new factors entered the power intelligence center as the input elements. Finally, in the intelligence handing background of PIC, by performing uncertain and recursive process to the input values of network, and combining unascertained mathematics, the novel load forecasting model was built. Three different approaches were put forward to forecast an eastern regional power grid load in China. The root mean square error (ERMS) demonstrates that the forecasting accuracy of the proposed model UMRNN is 3% higher than that of BP neural network (BPNN), and 5% higher than that of autoregressive integrated moving average (ARIMA). Besides, an example also shows that the average relative error of the first quarter of 2008 forecasted by UMRNN is only 2.59%, which has high precision.
基金Project(70373017) supported by the National Natural Science Foundation of China
文摘Considering the factors affecting the increasing rate of power consumption, the BP neural network structure and the neural network forecasting model of the increasing rate of power consumption were established. Immune genetic algorithm was applied to optimizing the weight from input layer to hidden layer, from hidden layer to output layer, and the threshold value of neuron nodes in hidden and output layers. Finally, training the related data of the increasing rate of power consumption from 1980 to 2000 in China, a nonlinear network model between the increasing rate of power consumption and influencing factors was obtained. The model was adopted to forecasting the increasing rate of power consumption from 2001 to 2005, and the average absolute error ratio of forecasting results is 13.521 8%. Compared with the ordinary neural network optimized by genetic algorithm, the results show that this method has better forecasting accuracy and stability for forecasting the increasing rate of power consumption.
基金supported by the National Natural Science Foundation of China (4177402141974005)。
文摘Electric power is widely used as the main energy source of ship integrated power system(SIPS), which contains power network and electric power network. SIPS network reconfiguration is a non-linear large-scale problem. The reconfiguration solution influences the safety and stable operation of the power system. According to the operational characteristics of SIPS, a simplified model of power network and a mathematical model for network reconfiguration are established. Based on these models, a multi-agent and ant colony optimization(MAACO) is proposed to solve the problem of network reconfiguration. The simulations are carried out to demonstrate that the optimization method can reconstruct the integrated power system network accurately and efficiently.
基金Projects(61101104,61100213) supported by the National Natural Science Foundation of ChinaProject(NY211050) supported by Fund of Nanjing University of Posts and Telecommunications,China
文摘A distributed local adaptive transmit power assignment (LA-TPA) strategy was proposed to construct a topology with better performance according to the environment and application scenario and prolong the network lifetime.It takes the path loss exponent and the energy control coefficient into consideration with the aim to accentuate the minimum covering district of each node more accurately and precisely according to various network application scenarios.Besides,a self-healing scheme that enhances the robustness of the network was provided.It makes the topology tolerate more dead nodes than existing algorithms.Simulation was done under OMNeT++ platform and the results show that the LA-TPA strategy is more effective in constructing a well-performance network topology based on various application scenarios and can prolong the network lifetime significantly.
文摘Subsurface cavities are very susceptible subsurface locations for down-lifting of a dam construction.In order to detect the low-density zones of a power plant a micro-gravity survey was conducted in a site considered for construction of a power plant site in Iran.First we gain the residual anomalies through bouger anomalies and then we design an Artificial Neural Network(ANN)which is trained by a set of training data.The ANN was tested for both synthetic and real data.For real data some suitable features are derivate from residual anomalies and applied to
基金Supported by National Natural Science Foundation of P. R. China (60434030, 60673178)
文摘The data gathering manner of wireless sensor networks, in which data is forwarded towards the sink node, would cause the nodes near the sink node to transmit more data than those far from it. Most data gathering mechanisms nowdo not do well in balancing the energy consumption among nodes with different distances to the sink, thus they can hardly avoid the problem that nodes near the sink consume energy more quickly, which may cause the network rupture from the sink node. This paper presents a data gathering mechanism called PODA, which grades the output power of nodes according to their distances from the sink node. PODA balances energy consumption by setting the nodes near the sink with lower output power and the nodes far from the sink with higher output power. Simulation results show that the PODA mechanism can achieve even energy consumption in the entire network, improve energy efficiency and prolong the network lifetime.
基金Supported by China Postdoctoral Science Foundation(20090460873)
文摘In view of the serious reactive power loss in the rural network, improved ant colony optimization algorithm （ACOA） was used to optimize the reactive power compensation for the rural distribution system. In this study, the traditional ACOA was improved in two aspects： one was the local search strategy, and the other was pheromone mutation and re-initialization strategies. The reactive power optimization for a county＇s distribution network showed that the improved ACOA was practicable.
文摘Rural power network planning is a complicated nonlinear optimized combination problem which based on load forecasting results, and its actual load is affected by many uncertain factors, which influenced optimization results of rural power network planning. To solve the problems, the interval algorithm was used to modify the initial search method of uncertainty load mathematics model in rural network planning. Meanwhile, the genetic/tabu search combination algorithm was adopted to optimize the initialized network. The sample analysis results showed that compared with the certainty planning, the improved method was suitable for urban medium-voltage distribution network planning with consideration of uncertainty load and the planning results conformed to the reality.
