摘要
近年来,子宫内膜异位症相关性卵巢癌的研究取得了重大进展。本文全面回顾了EAOC的发病机制、风险因素、诊断方法和治疗策略的最新研究成果。研究显示,遗传突变如ARID1A和PI3K/AKT通路的异常活化是EAOC发病的重要因素。此外,患者的遗传背景、生活方式和环境因素也与EAOC的风险密切相关。在诊断方面,新型生物标志物和先进的成像技术正在被开发以提高早期诊断的准确性。治疗方面,除了传统的手术和化疗,靶向疗法和免疫治疗显示了良好的治疗前景。特别是,PD-1/PD-L1抑制剂在提高某些EAOC患者的生存率方面表现出较大潜力。未来研究需要进一步探索EAOC的病理机制,优化诊断策略,并发展更加个性化的治疗方案。
Recent years have seen significant advancements in the study of endometriosis associated ovarian cancer (EAOC). This article provides a comprehensive review of the latest research findings on the pathogenesis, risk factors, diagnostic methods, and therapeutic strategies for EAOC. Studies indicate that genetic mutations such as ARID1A and aberrant activation of the PI3K/AKT pathway are crucial factors in the development of EAOC. Additionally, the genetic background, lifestyle, and environmental factors of patients are closely associated with the risk of EAOC. In terms of diagnosis, novel biomarkers and advanced imaging techniques are being developed to enhance the accuracy of early detection. Therapeutically, beyond traditional surgery and chemotherapy, targeted therapies and immunotherapies have shown promising prospects. Particularly, PD-1/PD-L1 inhibitors have demonstrated substantial potential in improving survival rates for certain EAOC patients. Future research needs to further explore the pathological mechanisms of EAOC, optimize diagnostic strategies, and develop more personalized treatment plans.
出处
《临床医学进展》
2024年第6期594-601,共8页
Advances in Clinical Medicine
