摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是最常见的慢性肝病之一,早期症状隐匿,疾病发展后期可严重危害人体健康。微小RNA (miRNA)是一种由少量核苷酸组成的非编码RNA,在多种生物过程中发挥重要作用。微小RNA-21 (miR-21)与NAFLD的发生发展有着紧密联系。目前,NAFLD的发病机制尚不清楚,临床上缺乏特异性的早期诊断方法。本文就miR-21在NAFLD发生发展中的作用机制进行综述,并探讨其在NAFLD早期诊断中的价值。
Non-alcoholic Fatty Liver Disease (NAFLD) is one of the most common chronic liver diseases in the world. The early symptoms are occult and the later stages of disease development can seriously harm human health. At present, the specific pathogenesis of NAFLD is not clear, and there is a lack of specific clinical early diagnosis methods. MicroRNAs (miRNAs) are non-coding RNAs composed of a small number of nucleotides that play an important role in a variety of biological processes. Pre-vious studies have shown that MicroRNA-21 (miR-21) is closely related to the occurrence and de-velopment of NAFLD. This paper reviews the mechanism of miR-21 in the occurrence and develop-ment of NAFLD, and discusses its value in the early diagnosis of NAFLD.
出处
《临床医学进展》
2022年第12期11611-11617,共7页
Advances in Clinical Medicine
