摘要
目前全球仍面临着癌症的疾病负担,YAP (Yes-associated protein)作为Hippo信号通路的中央调节器,对组织生长修复、器官大小和干细胞的重编程起着重要的调控作用。本文综述了YAP的最新研究进展、在各个系统中YAP的表达情况以及部分致癌机制,为癌症治疗新靶点的研究提供相关理论依据。
Currently, the world is still facing the disease burden of cancer. As the central regulator of Hippo signaling pathway, YAP (YES-associated protein) plays an important role in regulating tissue growth, repair, organ size and stem cell reprogramming. This paper reviews the latest research progress of YAP, the expression of YAP in various systems and some carcinogenic mechanisms, providing relevant theoretical basis for the study of new targets for cancer treatment.
出处
《临床医学进展》
2022年第5期4758-4764,共7页
Advances in Clinical Medicine
