摘要
目的探讨壹期煤工尘肺(CWP)患者血清肿瘤蛋白53(p53)、B淋巴细胞瘤-2蛋白(Bcl-2)水平变化及意义。方法用酶联免疫法检测88例壹期CWP患者(CWP组)、53例井下健康煤矿工人(接尘组)及35例井上健康工人(非接尘组)血清p53和Bcl-2水平。结果与非接尘组和接尘组比较,CWP组p53和Bcl-2水平均升高,差异均有统计学意义(均P<0.01);接尘组Bcl-2水平高于非接尘组,差异有统计学意义(P<0.01),p53水平无明显变化(P>0.05);CWP患者中>30年接尘时间组Bcl-2水平高于<20年接尘时间组,差异有统计学意义(P<0.05)。CWP患者血清p53和Bcl-2水平呈轻度正相关(rs=0.263,P<0.05)。结论壹期CWP患者血清p53和Bcl-2水平升高与尘肺发生发展有关;Bcl-2水平改变可能与接尘时间有关。
[Objective]To explore the changes and significance of serum tumor protein 53(p53)and B-cell lymphoma-2(Bcl-2)in patients with stageⅠcoal workers’pneumoconiosis(CW P).[Methods]Serum levels of p53 and Bcl-2 were determined in 88 CWP patients(CWP group),53 healthy undergr ound coal workers(dust-exposed group)35 healthy ground workers(non-dust exposed group)by ELISA.[Results]Serum levels of p53 and Bcl-2 in CWP group were significantly higher than those in dustexposed group and non-dust-exposed group(all P<0.01).Bcl-2 level in dust-exposed group were significantly higher than that in non-dust-exposed(P<0.01),and the difference in p53 level was not statistically significant(P>0.05).In CWP group,Bcl-2 level in patients with dust-exposed durations more than 30 years was higher than that in those with dust-exposed durations less than 20 years(P<0.05).In CWP patients,there was a slight positive correlation between p53 level and Bcl-2 level(rs=0.263,P<0.05).[Conclusion]In stageⅠpatients,the serum levels of p53 and Bcl-2 are elevated and associated with the development of the CWP.The changes of the serum Bcl-2 level may be related to the dust-exposed durations.
作者
袁宝军
李超
王冬梅
崔晶晶
高利常
佟艳艳
YUAN Bao-jun;LI Chao;WANG Dong-mei;CUI Jing-jing;GAO Li-chang;TONG Yan-yan(Laboratory Department,Kailuan General Hospital,Tangshan Hebei 063000,China)
出处
《职业与健康》
CAS
2019年第7期896-899,共4页
Occupation and Health
作者简介
袁宝军,男,教授,主任技师,主要从事临床免疫学检验及相关研究工作。
