摘要
骨是晚期恶性肿瘤最常见的转移部位之一。在正常情况下,骨重建是一个平衡的过程,是破骨细胞不断吸收旧骨和成骨细胞不断形成新骨的过程。当恶性肿瘤发生骨转移时,骨转移灶的骨代谢失去平衡。骨代谢标志物已被证实能反映肿瘤导致的骨代谢的变化。本文就骨代谢标志物在骨转移瘤早期诊断、病情判断、疗效监测及预后评估等方面的应用进行综述,以探讨它们的临床应用价值。
Bone metastases are frequent and seen in many malignancies.Under normal conditions,the bone remodelling process is a balanced,lifelong continuum of resorbing old bone and replacing the removed tissue by an equal amount of newly formed bone.The presence of bone metastases greatly perturbs the balance of normal bone remodeling.Biochemical markers of bone metabolism have been shown to reflect these tumor-induced changes in bone remodeling.This review summarized the available evidence on the clinical application of bone metabolism markers in diagnostic,prognostic,and monitoring purposes for patients with bone metastases.
出处
《中华临床医师杂志（电子版）》
CAS
2017年第8期1388-1391,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
广东省佛山市医学类科技攻关项目(201308168)
关键词
骨代谢标志物
骨转移
诊断
预后
】 Biochemical markers of bone metabolism
Bone metastases
Diagnosis
Prognosis
