摘要
目的观察肺癌骨转移患者放疗前后血清Ⅰ型胶原羧基端肽β特殊序列(β-CTX)和Ⅰ型前胶原N-端前肽(PINP)的变化,并分析其与放疗疗效的关系。方法对28例肺癌骨转移患者均给予6 MV X线放射治疗,每周5次,3 Gy/F,总剂量30 Gy。放疗后评价疗效,放疗前后电化学发光法检测血清β-CTX和PINP,比较放疗前后血清β-CTX和PINP变化及其与放疗疗效的关系。结果肺癌骨转移患者放疗后止痛效果为完全缓解9例、部分缓解10例、无缓解9例、有效率为67.86%,血清β-CTX和PINP水平均较放疗前明显下降(P均<0.05)。放疗有效者放疗后血清β-CTX、PINP水平较放疗前明显下降(P均<0.05),放疗无效者放疗后血清PINP水平较放疗前有所下降(P<0.05),β-CTX略有下降,但差异无统计学意义(P>0.05)。结论肺癌骨转移患者放疗后血清β-CTX和PINP较放疗前降低,二者可作为肺癌骨转移患者放疗疗效评价的辅助指标。
Objective To investigate the clinical significance of β isomer of C-terminal telopeptide( β-CTX) and amino-terminal propeptide of type I collagen( PINP) in lung cancer patients with bone metastasis before and after radiotherapy. Methods A total of 28 lung cancer patients with bone metastasis were enrolled in this study. Serum β-CTX and PINP were measured before and after radiotherapy. The relationship between the level of serum β-CTX,PINP before and after radiotherapy and the response to radiotherapy were analyzed. Results 9 cases had complete remission of pain after radiotherapy,10 cases partial remission,9 cases no remission,the effective rate was 67. 86%. Compared with pre-radiotherapy,the levels of β-CTX and PINP deceased after radiotherapy( both P < 0. 05). For radiotherapy responding group,the levels of β-CTX and PINP decreased after radiotherapy( both P < 0. 05). For radiotherapy non-responding group,the level of PINP decreased( P < 0. 05),while β-CTX slightly decreased( P > 0. 05). Conclusions The levels of β-CTX and PINP in serum of lung cancer patients with bone metastasis measurement after radiotherapy decreased compare with before radiotherapy,which might be as valuable index to monitor radiotherapy response.
出处
《山东医药》
CAS
北大核心
2015年第8期31-33,共3页
Shandong Medical Journal
基金
广东省佛山市医学类科技攻关项目(201308168)
