摘要
本文用头孢霉素Ⅱ,马桑内酯,印防已毒素和青霉素造成清醒大鼠实验性癫痫发作,研究了东亚钳蝎毒抗癫痫肽(AEP)的抗癫痫作用,比较了AEP与已知抗癫痫药在作用方式及特点上的异同。实验表明,AEP对上述4种模型癫痫发作有明显的抑制作用,在不同的模型上表现了不同的方式及性质。与苯妥英钠、卡马西平和抗癫痫灵相比,AEP作用强,用量小,毒性低;在印防已毒素模型上作用与苯妥英钠相似,在青霉素模型上作用与抗痫灵相似。
It is reported in this paper that anti-epilepsy peptide(AEP), obtained from the venom of Buthus martensii karsch has inhibitive effect on seizures induced by cephaloridine,lactoni coriae,picrotoxinand,penicillin in unanesthetized rats, Also reported are the similarities and differences in mode and nature between AEP and other known anti-epileptic drugs. AEP inhibts effectively seizure, exhibiting different mode and nature in different experimental seizure models. In picrotoxin seizure, AEP acts similarly to sodium phenytion, and differently in three other kinds of experimental seizures. Also AEP inhibits the frequency of epileptiform discharges induced by penicillin,much like that of anti-epidepsirium whereas carbamazepine and sodium phenytoin do not affect the frequency in unanesthetized rats.
基金
1987~1989年国家青年自然科学资金资助项目
关键词
东亚钳蝎毒
抗癫痫肽
Venom of Buthus Martensii Karsch
Anti-epilepsy peptide
Epileptic model
