摘要
目的正交试验优选白芷纳米乳鼻喷雾剂的提取工艺。方法以欧前胡素提取量、香豆素提取量总量和浸膏得率的综合评分为评价指标,在单因素试验基础上,采用正交试验优选白芷醇提工艺的溶剂体积、乙醇浓度、提取时间。结果优选得到白芷纳米乳鼻喷雾剂最佳醇提工艺为:以85%乙醇为提取溶剂,第1次6倍量1.5h,第2次5倍量1h,共提取2次。结论在单因素试验基础上,通过正交试验优选的提取工艺经验证稳定、简便易行,预测性好,为白芷纳米乳鼻喷雾剂的工艺研究提供了依据。
Objective To optimize extraction process of Baizhi nanoscale spray for nose by orthogonal design.Methods On the basis of single factor tests,orthogonal design was employed to investigate effects of the extraction time,the alcohol addition and the alcohol concentration.Results The optimization processing parameters was as follows:added 6 times volume of 85%of ethanol and 5 times volume of 85%of ethanol separately,extracted for twice,the first 1.5 hours then 1 hour.Conclusion This optimized extraction experience proved to be stable,simple,good predictability by orthogonal design,it provides the basis for technology research of Baizhi nanoscale spray for nose.
作者
陈玲珑
李跃辉
CHEN Ling-long;LI Yue-hui(Affiliated Hosptol of Hunan Academy of Tradtional Chinese Medicine,Changsha,Hunan 410006,China;Hunan Academy of Traditional Chinese Medicine,Changsha,Hunan 410006,China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2019年第2期351-353,共3页
Lishizhen Medicine and Materia Medica Research
基金
湖南省中医药管理局重点项目(201726)
关键词
白芷纳米乳鼻喷雾剂
正交试验
欧前胡素
香豆素
浸膏得率
Baizhi nanoscale spray for nose
Orthogonal design
Imperatorin
Coumarin
Yield of extract
作者简介
陈玲珑(1981-),女(汉族),湖南邵阳人,湖南省中医药研究院附属医院主管药师,硕士学位,主要从事制剂及质量控制研究工作;通讯作者:李跃辉(1978-),女(汉族),湖南益阳人,湖南省中医药研究院研究员,硕士学位,主要从事中药制剂研究及分析工作.
