摘要
目的探讨血清前列腺特异性抗原(PSA)、前列腺特异性抗原密度(PSAD)检测在前列腺癌(PCa)骨转移诊断中的价值。方法经前列腺穿刺活检或手术后病理检查确诊的238例PCa患者,根据ECT、X线、CT及MRI结果诊断骨转移组112例、非骨转移组126例;分析血清PSA、PSAD水平与PCa骨转移的关系。结果以血清PSA>20 ng/m L为骨转移诊断标准,两组骨转移阳性率有统计学差异(P<0.05),其诊断骨转移敏感度性76.79%,特异性为82.54%。以血清PSAD>0.40 ng/(m L·cm3)为骨转移诊断标准,两组骨转移阳性率有统计学差异(P<0.05),其诊断骨转移敏感性82.14%,特异性为75.40%。以血清PSA>20 ng/m L联合PSAD>0.40 ng/(m L·cm3)为临界值诊断骨转移敏感性、特异性分别为82.14%和84.13%。应用ROC曲线确定诊断PCa骨转移的临界值,血清PSA为20 ng/m L,PSAD为0.40 ng/(m L·cm3)。结论血清PSA、PSAD均为判断PCa患者有无骨转移的可靠指标,PSA+PSAD联合检测有助于预测PCa骨转移。
Objective To investigate the clinical value of PSA,PSAS on prostate cancer with bone metastasis. Methods A total of 238( a group of 112 cases of bone metastasis,a group of 126 cases of non-bone metastasis) patients with histologically diagnosed prostate cancer were analyzed. ECT,X-ray,CT and MRI were used to diagnose bone metastasis. Relation among serum PSA and PSAD joint detection and bone metastasis were analyzed. Results According to serum PSA > 20 ng / m L diagnostic criteria of bone metastasis,the rate of bone metastasis had significant difference between the two groups( P< 0. 05),the sensitivity and specificity were 76. 79% and 82. 54%,respectively. According to serum PSAD > 0. 40 ng /( m L·cm3) diagnostic oriteria of bone metastasis,the rate of bone metastasis had significant differenc between the two groups( P< 0. 05),the sensitivity and specificity were 82. 14% and 75. 40%,respectively. The sensitivity and specificity of serum PSA + PSAD were 82. 14% and 84. 13%,respectively. Using ROC curve to determine the diagnosis critical value of PCa bone metastases,the best critical value of serum PSA was 20 ng / m L and the best critical value of serum PSAD both 0. 40 ng /( m L·cm3). Conclusions Serum PSA and PSAD are both valuable parameters used in prediction of PCa bone metastasis.Serum PSA and PSAD joint detection can be better to help doctor predicting PCa bone metastasis.
出处
《山东医药》
CAS
北大核心
2015年第5期1-3,6,共4页
Shandong Medical Journal
基金
天津市应用基础及前沿技术研究计划(12JCYBJC31400)
天津市科委抗癌重大专项攻关计划项目(12ZCDZSY16300)
