摘要
目的:研究白芥子提取物抑制前列腺增生的活性成分和作用机理。方法:采用丙酸睾酮诱导的去势小鼠前列腺增生;组胺诱导的小鼠皮肤毛细血管通透性增加;滤纸片埋藏诱发的大鼠皮下肉芽肿为动物模型。从白芥子提取物中分离得到的白芥子苷和白芥子β-谷甾醇为药效研究对象。结果:白芥子苷(16.0,8.0mg·kg^(-1)·d^(-1))和β-谷甾醇(16.0,8.0 mg·kg^(-1)·d^(-1))均能明显降低由丙酸睾酮诱发的去势小鼠前列腺增生,降低小鼠血清酸性磷酸酶活力(P<0.01或P<0.05);白芥子苷(16.0 mg·kg^(-1)·d^(-1))能明显降低滤纸片埋藏引起的大鼠肉芽肿增殖(P<0.05);β-谷甾醇(8.0,16.0 mg·kg^(-1)·d^(-1))能明显降低组胺诱发的小鼠毛细血管通透性增加(P<0.05)。结论:白芥子苷、β-谷甾醇具有抗雄激素和抗炎活性。
Objective: To study the active components and their functionary mechanism of the extract of Brassica alba seeds, which inhibits experimental mice prostatic hyperplasia. Method: Prostatic hyperplasia of castrated male mice induced by testosterone propionate, the penetrability of capillary vessel of mice skin induced by histamine and the endermic flesh bud of rat induced by filter paper were used as experimental models. Sinalbin and β-sitosterol seperated from seeds of Brassica alba were used to test the activities. Result: Sinalbin and β-sitosterol(16.0 mg·kg-1·d-1 and 8.0 mg·kg-1·-1)could significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase(P<0.01 or P<0.05), Sinalbin(16.0 mg·kg-1·d-1)could significantly inhibit the hyperplasia of endermic flesh bud in rat induced by filter paper(P<0.05), bbbbbb-sitosterol(16.0 mg·kg-1·d-1 and 8.0 mg·kg-1·d-1)could significantly decrease the penetrability of capillary vessel of mice skin induced by histamine. Conclusion: Sinalbin and bbbbbb-sitosterol have anti-androgen and anti-inflammation activities.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2003年第7期643-646,共4页
China Journal of Chinese Materia Medica
基金
福建省科技项目基金(K99023)
关键词
前列腺增生
白芥子苷
Β-谷甾醇
抗雄激素
抗炎
Seeds of Brassica alba
β-sitosterol
prostatic hyperplasia
anti-androgen
anti-inflammation
